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Rabbit Anti-MMP10/RBITC Conjugated antibody (bs-23106R-RBITC)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-23106R-RBITC
英文名稱(chēng)1 Rabbit Anti-MMP10/RBITC Conjugated antibody
中文名稱(chēng) 羅丹明(RBITC)標(biāo)記的基質(zhì)金屬蛋白酶-10抗體
別    名 Matrix metalloproteinase 10; Matrix metalloproteinase-10; matrix metalloproteinase 10; MMP-10; Mmp10; MMP10_HUMAN; SL 2; SL2; STMY 2; Stromelysin 2; Stromelysin II; Stromelysin-2; Stromelysin2; StromelysinII; Transin 2; Transin-2; Transin2; stromelysin 2; SL-2; STMY2; MMP 10; AV377895, MMP10.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  合成與降解  細(xì)胞外基質(zhì)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MMP10
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Function:
Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.

Subcellular Location:
Secreted, extracellular space, extracellular matrix (Probable).

Similarity:
Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains.

Database links:

Entrez Gene: 4319 Human

Entrez Gene: 17384 Mouse

Entrez Gene: 117061 Rat

Omim: 185260 Human

SwissProt: P09238 Human

SwissProt: O55123 Mouse

SwissProt: P07152 Rat

Unigene: 2258 Human

Unigene: 14126 Mouse

Unigene: 9946 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成與降解(Synthesis and Degradation)
MMP10主要用于一些惡性腫瘤,如乳腺癌、胃腸道癌、卵巢癌等與轉(zhuǎn)移浸潤(rùn)的研究。
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