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Rabbit Anti-GCLM/PE-Cy3 Conjugated antibody (bs-23360R-PE-Cy3)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-23360R-PE-Cy3
英文名稱1 Rabbit Anti-GCLM/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的γ 谷氨酰半胱氨酸連接酶調節亞基
別    名 Glutamate-Cysteine Ligase Modifier Subunit; Gamma-Glutamylcysteine Synthetase Regulatory Subunit; Glutamate--Cysteine Ligase Modifier Subunit; Gamma-ECS Regulatory Subunit; GCS Light Chain; GLCLR; Glutamate-Cysteine Ligase (Gamma-Glutamylcysteine Synthetase), Regulatory (30.8kD); Glutamate-Cysteine Ligase Modifier Subunit Delta2 Alternative Splicing; Glutamate--Cysteine Ligase Regulatory Subunit; Glutamate-Cysteine Ligase Regulatory Protein; Glutamate-Cysteine Ligase, Modifier Subunit; Gamma-Glutamylcysteine Synthetase; GSC Light Chain; GSH0_HUMAN;   
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  轉錄調節因子  合成與降解  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GCLM
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.05M PB, pH 7.5.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Function:
This protein is involved in step 1 of the subpathway that synthesizes glutathione from L-cysteine and L-glutamate.

Subunit:
Heterodimer of a catalytic heavy chain and a regulatory light chain.

Subcellular Location:
Cytosol

Tissue Specificity:
In all tissues examined. Highest levels in skeletal muscle.

Similarity:
Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.

Database links:

Entrez Gene: 2730 Human

Entrez Gene: 14630 Mouse

Entrez Gene: 29739 Rat

Omim: 601176 Human

SwissProt: P48507 Human

SwissProt: O09172 Mouse

SwissProt: P48508 Rat

Unigene: 315562 Human

Unigene: 292676 Mouse

Unigene: 2460 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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