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Rabbit Anti-AHNAK/Gold Conjugated antibody (bs-13624R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-13624R-Gold
英文名稱1 Rabbit Anti-AHNAK/Gold Conjugated antibody
中文名稱 膠體金標記的神經細胞分化相關蛋白AHNAK抗體
別    名 AHNAK; AHNAK nucleoprotein (desmoyokin); AHNAKRS; AHNK_HUMAN; Desmoyokin; Fragments; MGC5395; Neuroblast differentiation associated protein AHNAK; Neuroblast differentiation-associated protein AHNAK; PM227.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 心血管  神經生物學  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 629kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human AHNAK
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
AHNAK is a 5,890 amino acid protein encoded by the human gene AHNAK. The intronless AHNAK gene is located on human chromosome 11q12 and has three main structural regions: the 251 amino acid N-terminus, a large central region of 4390 amino acids with multiple repeated units of about 128 amino acids in length, and the 1002 amino acid C-terminus. The central region seems to have antiparallel beta-strands connected by intervening loops. Several putative regulatory elements are clustered within the C-terminal region, including nuclear export localization signals, a leucine zipper, and potential phosphorylation sites for Akt1 and PKC. AHNAK is believed to be an important signalling molecule involved in a wide range of physiological activities and may be required for neuronal cell differentiation.. AHNAK also appears to influence b-adrenergic regulation of cardiac L-type Ca2+ channel function.

Function:
May be required for neuronal cell differentiation.

Subunit:
Interacts with DYSF; the interaction is direct and Ca(2+)-independent.

Subcellular Location:
Nucleus.

Similarity:
Contains 1 PDZ (DHR) domain.

Database links:

Entrez Gene: 79026 Human

Entrez Gene: 66395 Mouse

Entrez Gene: 191572 Rat

Entrez Gene: 718802 Rhesus monkey

Omim: 103390 Human

SwissProt: Q09666 Human

Unigene: 502756 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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