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Rabbit Anti-TRIB1/Cy7 Conjugated antibody (bs-12343R-Cy7)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-12343R-Cy7
英文名稱1 Rabbit Anti-TRIB1/Cy7 Conjugated antibody
中文名稱 Cy7標(biāo)記的G蛋白偶聯(lián)誘導(dǎo)蛋白2受體抗體
別    名 Tribbles homolog 1; TRB-1; G-protein-coupled receptor-induced gene 2 protein; GIG-2; SKIP1; TRIB1_HUMAN; C8FW; GIG2; TRB1; Trib1; Tribbles homolog 1.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 發(fā)育生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞凋亡  激酶和磷酸酶  細(xì)胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Monkey, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 41kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Human TRIB1/GIG2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
TRB-1 is a 372 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase superfamily. Expressed ubiquitously with highest expression in bone marrow, thyroid gland, skeletal muscle and pancreas, TRB-1 interacts with MAPK kinases and is thought to regulate the activation of MAP kinses, possibly controlling MAP kinase cascades. The gene encoding TRB-1 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.

Function:
Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity.

Subcellular Location:
cytoplasm.

Tissue Specificity:
Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow.

Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 10221 Human

Entrez Gene: 211770 Mouse

Entrez Gene: 78969 Rat

Entrez Gene: 521857 Cow

Omim: 609461 Human

SwissProt: Q96RU8 Human

SwissProt: Q8K4K4 Mouse

Unigene: 444947 Human

Unigene: 40298 Mouse

Unigene: 204391 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Trib1在脂肪組織維持和脂質(zhì)代謝紊亂上發(fā)揮關(guān)鍵作用;
    巨噬細(xì)胞至少有兩個(gè)亞類,即M1型和M2型。M1型巨噬細(xì)胞參與促炎反應(yīng),且在宿主防御細(xì)菌和病毒感染中發(fā)揮核心作用。M2巨噬細(xì)胞與抗炎反應(yīng)、寄生蟲感染、組織重構(gòu)、纖維化以及腫瘤疾病發(fā)展相關(guān)。 Trib1是個(gè)銜接蛋白,與泛素連接酶COP1相互作用參與蛋白降解。人類全基因組關(guān)聯(lián)研究表明TRIB1參與脂質(zhì)代謝。
    日前,大阪大學(xué)WPI免疫前沿研究中心等處的研究人員,發(fā)現(xiàn)Trib1對(duì)F4/80 + MR +組織內(nèi)在巨噬細(xì)胞的分化至關(guān)重要,且這些巨噬細(xì)胞和M2巨噬細(xì)胞、酸性粒細(xì)胞具有共同的特性(稱之為M2類巨噬細(xì)胞)。但是,Trib1在M1髓系細(xì)胞就不會(huì)發(fā)揮這種作用。相關(guān)研究成果刊登在近期出版的《自然》(Nature)雜志上。
    Trib1缺陷導(dǎo)致各種器官中M2類巨噬細(xì)胞急劇減少,如骨髓、脾臟、肺以及脂肪組織。在Trib1缺失的骨髓細(xì)胞中,C / EBP α的異常表達(dá)要為巨噬細(xì)胞分化缺陷負(fù)責(zé)。沒有想到的是,造血細(xì)胞缺乏 Trib1的小鼠,減少了脂肪組織塊,并伴隨著脂肪分解增加,即使是在正常飲食條件下。
    M2類巨噬細(xì)胞的補(bǔ)充可緩解這種病理學(xué)現(xiàn)象。這表明,這類巨噬細(xì)胞的缺乏是引發(fā)脂肪分解的原因。為了應(yīng)對(duì)高脂肪飲食,造血細(xì)胞缺乏 Trib1的小鼠發(fā)育中會(huì)呈現(xiàn)高甘油三酯血癥、胰島素抗性,同時(shí)增加促炎細(xì)胞基因誘導(dǎo)。
    這些結(jié)果表明Trib1在脂肪組織維持和脂質(zhì)代謝紊亂上發(fā)揮關(guān)鍵作用,而其作用是通過控制組織內(nèi)在M2類巨噬細(xì)胞的分化實(shí)現(xiàn)的。
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