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Rabbit Anti-TRIB1/Cy3 Conjugated antibody (bs-12343R-Cy3)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-12343R-Cy3
英文名稱1 Rabbit Anti-TRIB1/Cy3 Conjugated antibody
中文名稱 Cy3標記的G蛋白偶聯誘導蛋白2受體抗體
別    名 Tribbles homolog 1; TRB-1; G-protein-coupled receptor-induced gene 2 protein; GIG-2; SKIP1; TRIB1_HUMAN; C8FW; GIG2; TRB1; Trib1; Tribbles homolog 1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 發育生物學  信號轉導  干細胞  細胞凋亡  激酶和磷酸酶  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Monkey, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 41kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Human TRIB1/GIG2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
TRB-1 is a 372 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase superfamily. Expressed ubiquitously with highest expression in bone marrow, thyroid gland, skeletal muscle and pancreas, TRB-1 interacts with MAPK kinases and is thought to regulate the activation of MAP kinses, possibly controlling MAP kinase cascades. The gene encoding TRB-1 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.

Function:
Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity.

Subcellular Location:
cytoplasm.

Tissue Specificity:
Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow.

Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 10221 Human

Entrez Gene: 211770 Mouse

Entrez Gene: 78969 Rat

Entrez Gene: 521857 Cow

Omim: 609461 Human

SwissProt: Q96RU8 Human

SwissProt: Q8K4K4 Mouse

Unigene: 444947 Human

Unigene: 40298 Mouse

Unigene: 204391 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Trib1在脂肪組織維持和脂質代謝紊亂上發揮關鍵作用;
    巨噬細胞至少有兩個亞類,即M1型和M2型。M1型巨噬細胞參與促炎反應,且在宿主防御細菌和病毒感染中發揮核心作用。M2巨噬細胞與抗炎反應、寄生蟲感染、組織重構、纖維化以及腫瘤疾病發展相關。 Trib1是個銜接蛋白,與泛素連接酶COP1相互作用參與蛋白降解。人類全基因組關聯研究表明TRIB1參與脂質代謝。
    日前,大阪大學WPI免疫前沿研究中心等處的研究人員,發現Trib1對F4/80 + MR +組織內在巨噬細胞的分化至關重要,且這些巨噬細胞和M2巨噬細胞、酸性粒細胞具有共同的特性(稱之為M2類巨噬細胞)。但是,Trib1在M1髓系細胞就不會發揮這種作用。相關研究成果刊登在近期出版的《自然》(Nature)雜志上。
    Trib1缺陷導致各種器官中M2類巨噬細胞急劇減少,如骨髓、脾臟、肺以及脂肪組織。在Trib1缺失的骨髓細胞中,C / EBP α的異常表達要為巨噬細胞分化缺陷負責。沒有想到的是,造血細胞缺乏 Trib1的小鼠,減少了脂肪組織塊,并伴隨著脂肪分解增加,即使是在正常飲食條件下。
    M2類巨噬細胞的補充可緩解這種病理學現象。這表明,這類巨噬細胞的缺乏是引發脂肪分解的原因。為了應對高脂肪飲食,造血細胞缺乏 Trib1的小鼠發育中會呈現高甘油三酯血癥、胰島素抗性,同時增加促炎細胞基因誘導。
    這些結果表明Trib1在脂肪組織維持和脂質代謝紊亂上發揮關鍵作用,而其作用是通過控制組織內在M2類巨噬細胞的分化實現的。
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