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Rabbit Anti-phospho-FSCN1(Ser39)/BF350 Conjugated antibody (bs-0772R-BF350)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-0772R-BF350
英文名稱1 Rabbit Anti-phospho-FSCN1(Ser39)/BF350 Conjugated antibody
中文名稱 BF350標記的磷酸化纖維束蛋白同源物1抗體
別    名 Fascin (phospho S39); Fascin (phospho S39); 55 kDa actin bundling protein; Actin bundling protein; FAN 1; FAN1; Fascin 1; Fascin homolog 1 actin bundling protein (Strongylocentrotus purpuratus); Fascin homolog 1; Fascin1; FLJ38511; FSCN 1; FSCN1; HSN; p55; Singed (Drosophila) like (sea urchin fascin homolog like); Singed drosophila homolog like; Singed like (fascin homolog sea urchin) (Drosophila); Singed like protein; SNL; Strongylocentrotus purpuratus.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 細胞生物  信號轉導  結合蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, Dog, Pig, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human FSCN1 around the phosphorylation site of Ser39
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Human fascin is a highly conserved actin-bundling protein. Fascin, encoded by the human homolog for sn (hsn) gene, has been localized to microspikes and stress fibers of cultured cells where it is thought to be involved in the formation of microfilament bundles. It is expressed predominantly in dendritic cells. Lymphoid cells, myeloid cells and plasma cells are negative. However, Reed Sternberg cells in Hodgkin’s lymphoma are positive for fascin staining. Epstein-Barr virus may induce expression of fascin in B cells.

Function:
Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.

Subcellular Location:
Cytoplasm > cytoskeleton. Cell projection > filopodium. Cell projection > invadopodium.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.

Similarity:
Belongs to the fascin family.

Database links:

Entrez Gene: 6624 Human

Entrez Gene: 14086 Mouse

Entrez Gene: 683788 Rat

Omim: 602689 Human

SwissProt: Q16658 Human

SwissProt: Q61553 Mouse

SwissProt: P85845 Rat

Unigene: 118400 Human

Unigene: 289707 Mouse

Unigene: 199526 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

肌動蛋白集束蛋白/圓線蟲紫癜抗體。
FSCN1為細胞骨架肌動蛋白的一種,該蛋白有蛋白結合,橋連、肌動蛋白絲結合的功能。 主要參與細胞增殖、肌動蛋白細胞骨架組織和生物發生、肌動蛋白絲束形成。<
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