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Rabbit Anti-HO-2/PE Conjugated antibody (bs-1238R-PE)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1238R-PE
英文名稱1 Rabbit Anti-HO-2/PE Conjugated antibody
中文名稱 PE標記的血紅素氧合酶2抗體
別    名 Heme oxygenase (decycling) 2; Heme oxygenase (decyclizing) 2; HMOX 2; HMOX2; HMOX2 protein; HO 2; HO2; HMOX2_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  神經生物學  合成與降解  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HO-2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Summary: catalyzes the conversion of heme to biliverdin; involved in cellular response to oxidative stress [SUBCELLULAR LOCATION] Microsome. Endoplasmic reticulum. [INDUCTION] Heme oxygenase 2 activity is non-inducible. [SIMILARITY] Belongs to the heme oxygenase family.

Function:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

Subcellular Location:
Microsome. Endoplasmic reticulum.

Similarity:
Belongs to the heme oxygenase family.
Contains 2 HRM (heme regulatory motif) repeats.

Database links:

Entrez Gene: 510243 Cow

Entrez Gene: 479864 Dog

Entrez Gene: 3163 Human

Entrez Gene: 15369 Mouse

Entrez Gene: 100009523 Rabbit

Entrez Gene: 79239 Rat

Omim: 141251 Human

SwissProt: P30519 Human

SwissProt: O70252 Mouse

SwissProt: P43242 Rabbit

SwissProt: P23711 Rat

Unigene: 284279 Human

Unigene: 272866 Mouse

Unigene: 10241 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成與降解(Synthesis and Degradation)
血紅素氧合酶是目前發現生物體內最易被誘導產生的抗氧化酶類,其抗氧化作用與它的催化分解產物即膽綠素、膽紅素、NO、鐵離子和鐵蛋白有關。
血紅素氧合酶-2基因缺失對血紅素誘導的氧化應激性導致的組織損傷具有保護作用;選擇性抑制神經元血紅素氧合酶-2基因的表達可減輕氧化應激性組織細胞損傷.
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