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Rabbit Anti-Cyclooxygenase 1/RBITC Conjugated antibody (bs-0582R-RBITC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-0582R-RBITC
英文名稱1 Rabbit Anti-Cyclooxygenase 1/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的前列腺素氧化環(huán)化酶1抗體
別    名 Cyclooxygenase-1; COX-1; COX 1; COX1; Cyclooxygenase1; Prostaglandin-endoperoxide synthase-1; prostaglandin-endoperoxide synthase 1; PTGS-1; Prostaglandin G/H synthase 1 precursor; prostaglandin G/H synthase 1 isoform 1 precursor; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; PGH1_HUMAN; PTGS1; Prostaglandin G/H synthase 1 precursor.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  心血管  免疫學  信號轉導  合成與降解  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Sheep, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 63kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cyclooxygenase 1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012].

Function:
May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.

Subunit:
Homodimer.

Subcellular Location:
Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.

Similarity:
Belongs to the prostaglandin G/H synthase family.
Contains 1 EGF-like domain.

Database links:

Entrez Gene: 5742 Human

Entrez Gene: 19224 Mouse

Entrez Gene: 24693 Rat

Omim: 176805 Human

SwissProt: P23219 Human

SwissProt: P22437 Mouse

SwissProt: Q63921 Rat

Unigene: 201978 Human

Unigene: 275434 Mouse

Unigene: 44404 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成與降解(Synthesis and Degradation)
COX1 前列腺素氧化環(huán)化酶-是前列腺素合成的關鍵酶之一,為誘導性酶,他參與細胞對生長因子、腫瘤促進因子和細胞因子的反應,這些因子均能誘導COX1表達,它也參與前列腺素的合成。
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