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Rabbit Anti-HECW1/PE-Cy3 Conjugated antibody (bs-11692R-PE-Cy3)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-11692R-PE-Cy3
英文名稱1 Rabbit Anti-HECW1/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的肌萎縮側索硬化癥相關蛋白HECW1抗體
別    名 NEDL1; C2 and WW domain-containing protein 1; E3 ubiquitin-protein ligase HECW1; HECT; HECT type E3 ubiquitin ligase; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1; HECT, C2 and WW domain-containing protein 1; HECW 1; Hecw1; HECW1_HUMAN; hNEDL1; NEDD4 like ubiquitin protein ligase 1; NEDD4-like E3 ubiquitin-protein ligase 1; NEDL-1; NEDL 1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  信號轉導  細胞凋亡  表觀遺傳學  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 179kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HECW1 (251-350aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
產品介紹 background:
NEDL1 is a 1,606 amino acid cytoplasmic protein predominantly expressed in neurons of adult and fetal brain. NEDL1 functions as an E3 ubiquitin-protein ligase that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme and transfers that ubiquitin residue to substrates targeted for degradation. NEDL1 mediates ubiquitination and subsequent degradation of Dvl-1 and targets mutant SOD-1. NEDL1 forms cytotoxic aggregates with Dvl, TRAP-?and mutant SOD1 that lead to motor neuron death in FALS (familial amyotrophic lateral sclerosis). individuals affect by FALS (also known as Lou Gehrig's disease) experience muscle weakness and atrophy throughout the body. FALS is caused by the degeneration of upper and lower motor neurons resulting in loss of signal to muscles.

Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.

Subunit:
Interacts with DVL1 and SSR3. Also interacts with mutant SOD1.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.

Similarity:
Contains 1 C2 domain.
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Contains 2 WW domains.

Database links:

Entrez Gene: 23072 Human

Omim: 610384 Human

SwissProt: Q76N89 Human

Unigene: 164453 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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