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Rabbit Anti-SLC10A1/Cy5.5 Conjugated antibody (bs-1958R-Cy5.5)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1958R-Cy5.5
英文名稱1 Rabbit Anti-SLC10A1/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標記的鈉離子/牛磺膽酸共轉運蛋白抗體
別    名 Na+/taurocholate Cotransporting Polypeptide; Na(+)/bile acid cotransporter; Cell growth-inhibiting gene 29 protein; Na / bile acid cotransporter; Na / taurocholate transport protein; Na(+)/taurocholate transport protein; NTCP; NTCP1; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1; Slc10a1 protein; Slc10a1; SBACT; SLC10A1; NTCP_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 免疫學  信號轉導  轉運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, Dog, Horse, Rabbit, )
產品應用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 38kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NTCP
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Sodium/bile acid cotransporters are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids, one absorbing from the intestinal lumen, the bile duct, and the kidney with an apical localization(SLC10A2; MIM 601295), and the other being found in the basolateral membranes of hepatocytes (SLC10A1).[supplied by OMIM]

Function:
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Liver and kidney

Similarity:
Belongs to the sodium:bile acid symporter family.

Database links:

Entrez Gene: 6554 Human

Entrez Gene: 20493 Mouse

Entrez Gene: 24777 Rat

Omim: 182396 Human

SwissProt: Q14973 Human

SwissProt: O08705 Mouse

SwissProt: P26435 Rat

Unigene: 952 Human

Unigene: 341781 Mouse

Unigene: 9913 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

NTCP(鈉離子/牛磺膽酸共轉運蛋白)(鈉離子-牛磺膽酸共轉運多肽)Na+/taurocholate Cotransporting Polypeptide是 肝臟的膽汁酸鹽吸收主要是鈉離子依賴性轉運子NTCP介導的,主要吸收牛磺膽酸,是肝細胞特有的一種轉運載體,分布在肝細胞基側膜在肝小葉和肝的腺泡表達較多。
有學者認為:NTCP是乙肝病毒的細胞表面受體分子,是HBV和HDV的功能受體,這些研究將有待于科研人員的進一步證實。
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