| 產品編號 | bs-2595R-Gold |
| 英文名稱1 | Rabbit Anti-IL-1R2/Gold Conjugated antibody |
| 中文名稱 | 膠體金標記的白介素1受體2抗體 |
| 別 名 | IL1 Receptor II; IL-1R II; IL1 Receptor 2; interleukin-1 receptor type 2 precursor; IL1R2; CD121b; IL1RB; CD121; CD121 antigen-like family member B; CD121b; CD121B Antigen; CDW121B; IL-1R-2; IL-1R-beta; IL-1R2; IL-1RT-2; IL-1RT2; IL1R Beta; Il1r-2; IL1R2; IL1RB; Interleukin 1 receptor, beta, type II; Interleukin 1 receptor, type II; Interleukin-1 receptor beta; Interleukin-1 receptor type 2; MGC137383; MGC47725; p68; IL1 Receptor II; IL1R2_HUMAN. |
| 規格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul（10nm 15nm 35nm） |
| 研究領域 | 免疫學 干細胞 淋巴細胞 b-淋巴細胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Rat, (predicted: Mouse, Dog, ) |
| 產品應用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL-1R II |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產品介紹 |
background: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4(IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq]. Function: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Subcellular Location: Isoform Short: Secreted. Isoform Long: Cell membrane; Single-pass type I membrane protein. Post-translational modifications: A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported. Similarity: Belongs to the interleukin-1 receptor family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Database links: Entrez Gene: 7850 Human Omim: 147811 Human SwissProt: P27930 Human Unigene: 25333 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. IL-1RⅡ屬于新的信號受體家族Toll信號轉導通路蛋白，IL-1RⅡ在免疫和炎癥反應的研究中占重要地位，是在很多感染 、炎癥性致病機制中起決定性作用的細胞因子，幾乎可作用于全身各種細胞，IL-1 與IL-1RⅡ的結合可導致大量與免疫反應和炎癥相關基因的表達 ，包括細胞因子、細胞因子受體、急性期反應物、生長因子、胞外基質、粘附分子等。IL-1RⅡ/NF-κB信號通路是機體免疫反應中十分重要的組成部分。 |
| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
