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Rabbit Anti-Cathepsin B/PE-Cy3 Conjugated antibody (bs-1500R-PE-Cy3)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1500R-PE-Cy3
英文名稱1 Rabbit Anti-Cathepsin B/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的組織蛋白酶B抗體
別    名 Amyloid precursor protein secretase; APP secretase; APPS; Cathepsin B; CB; Cathepsin B1; CathepsinB; CPSB; CTSB; Cysteine protease; Preprocathepsin B; Cathepsin B heavy chain; Cathepsin B light chain; CATB_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  免疫學  合成與降解  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, 
產品應用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 23/28/37kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cathepsin B heavy chain
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.

Subunit:
Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2.

Subcellular Location:
Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Similarity:
Belongs to the peptidase C1 family.

Database links:

Entrez Gene: 1508 Human

Entrez Gene: 13030 Mouse

Entrez Gene: 64529 Rat

Omim: 116810 Human

SwissProt: P07858 Human

SwissProt: P10605 Mouse

SwissProt: P00787 Rat

Unigene: 520898 Human

Unigene: 236553 Mouse

Unigene: 472420 Mouse

Unigene: 100909 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成與降解(Synthesis and Degradation)
組織蛋白酶B(CB) 參與腫瘤的侵襲轉移過程。可促進腫瘤血管的增生,增強腫瘤細胞的運動能力.組織蛋白酶B轉錄以及表達水平的高低與腫瘤預后呈正相關。
cathepsin B屬于半胱氨酸蛋白酶,與人體的多種生理、病理過程密切相關.組織蛋白酶B (cathepsin B,CB)主要存在于溶酶體中, 發揮其生理狀態下的蛋白水解作用.但在某些特定條件下, CB在胞外間質中有時也可以檢測到.
目前,有學者將CB用于阿爾茨海默病(AD)方面的研究。
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