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Rabbit Anti-FASN/PE-Cy5.5 Conjugated antibody (bs-1498R-PE-Cy5.5)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1498R-PE-Cy5.5
英文名稱1 Rabbit Anti-FASN/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的脂肪酸合成酶抗體
別    名 fatty acid synthase; FASN; FAS; FA Synthase 1; MGC14367; MGC15706; OA-519; Fatty acid synthase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-oxoacyl-[acyl-carrier-protein] synthase; Enoyl-[acyl-carrier-protein] reductase; Oleoyl-[acyl-carrier-protein] hydrolase; FAS_MOUSE.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  心血管  免疫學  神經生物學  信號轉導  激酶和磷酸酶  合成與降解  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Sheep, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 272kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse FASN
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
FASN (Fatty Acid Synthase) is a central enzyme in de novo lipogenesis. FAS is a target for SREBP and is upregulated by LXR activation; it is also one of the accepted markers for insulin resistance, SREBP and LXR activation.

Function:
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.

Subunit:
Homodimer which is arranged in a head to tail fashion.

Subcellular Location:
Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Tissue Specificity:
Ubiquitous. Prominent expression in brain, lung, and liver.

Similarity:
Contains 1 acyl carrier domain.

Database links:

Entrez Gene: 2194 Human

Entrez Gene: 14104 Mouse

Entrez Gene: 50671 Rat

Entrez Gene: 281152 Cow

Omim: 600212 Human

SwissProt: P12276 Chicken

SwissProt: Q71SP7 Cow

SwissProt: P49327 Human

SwissProt: P19096 Mouse

SwissProt: P12785 Rat

Unigene: 8951 Chicken

Unigene: 30099 Cow

Unigene: 83190 Human

Unigene: 236443 Mouse

Unigene: 9486 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成與降解(Synthesis and Degradation)
脂肪酸合成酶fatty acid synthase是一種新的腫瘤標志物,高表達常提示腫瘤的預后不良.
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