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Rabbit Anti-MMP10/Gold Conjugated antibody (bs-1344R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1344R-Gold
英文名稱1 Rabbit Anti-MMP10/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的基質(zhì)金屬蛋白酶-10抗體
別    名 Matrix metalloproteinase 10; Matrix metalloproteinase-10; matrix metalloproteinase 10; MMP-10; Mmp10; MMP10_HUMAN; SL 2; SL2; STMY 2; Stromelysin 2; Stromelysin II; Stromelysin-2; Stromelysin2; StromelysinII; Transin 2; Transin-2; Transin2; stromelysin 2; SL-2; STMY2; MMP 10; AV377895, MMP10.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  細(xì)胞外基質(zhì)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MMP10
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Function:
Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.

Subcellular Location:
Secreted, extracellular space, extracellular matrix (Probable).

Similarity:
Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains.

Database links:

Entrez Gene: 4319 Human

Entrez Gene: 17384 Mouse

Entrez Gene: 117061 Rat

Omim: 185260 Human

SwissProt: P09238 Human

SwissProt: O55123 Mouse

SwissProt: P07152 Rat

Unigene: 2258 Human

Unigene: 14126 Mouse

Unigene: 9946 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成與降解(Synthesis and Degradation)
MMP10主要用于一些惡性腫瘤,如乳腺癌、胃腸道癌、卵巢癌等與轉(zhuǎn)移浸潤的研究。
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