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Rabbit Anti-CD23  antibody (bsm-60453R)  
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產品編號 bsm-60453R
英文名稱 Rabbit Anti-CD23  antibody
中文名稱 CD23重組兔單抗
別    名 Fc EpsilonR II; FcεRII; Blast 2; Blast2; C type lectin domain family 4 member J; C-type lectin domain family 4, member J; CD 23; CD 23A; CD23 antigen; CD23A; CLEC 4J; CLEC4J; Fc epsilon RII; Fc fragment of IgE low affinity II receptor for; Fc fragment of IgE, low affinity II, receptor for (CD23); Fc of IgE, low affinity II, receptor for (CD23); Fc receptor IgE low affinity II alpha polypeptide; Fc receptor, IgE, low affinity II, alpha polypeptide, isoform CRA_a; FCE 2; FCE2; FCER 2; FCER2; FCER2A; IgE binding factor; IgE receptor lymphocyte; IgE-binding factor; IGEBF; Immunoglobulin E binding factor; Immunoglobulin E receptor, low affinity II; Low affinity immunoglobulin epsilon Fc receptor; Low affinity immunoglobulin epsilon Fc receptor membrane bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form; Ly-42; Ly42; Lymphocyte antigen CD23; Lymphocyte IgE receptor; MGC93219.  
研究領域 細胞生物  免疫學  干細胞  細胞類型標志物  淋巴細胞  t-淋巴細胞  
抗體來源 Rabbit
克隆類型 Recombinant
克 隆 號 C2F9
交叉反應 Human
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 36kDa
細胞定位 細胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD23  
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Function:
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Subcellular Location:
Cell membrane; Single-pass type II membrane protein. Secreted. Note=Also exists as a soluble excreted form.

Post-translational modifications:
N- and O-glycosylated.

Similarity:
Contains 1 C-type lectin domain.

SWISS:
P06734

Gene ID:
2208

Database links:

Entrez Gene: 2208 Human

Entrez Gene: 14128 Mouse

Omim: 151445 Human

SwissProt: P06734 Human

SwissProt: P20693 Mouse

Unigene: 465778 Human

Unigene: 1233 Mouse



CD23是一種II型跨膜糖蛋白,是存在于B細胞表面的IgE受體。在慢性B淋巴細胞白血病(CLL)和小B細胞淋巴瘤(SLL)為陽性,套細胞淋巴瘤和小核裂淋巴細胞淋巴瘤陰性。也表達于外周血B細胞的某些亞型、B淋巴細胞和EB病毒轉染的B淋巴瘤細胞系。CD23是慢性B淋巴細胞白血病,小B細胞淋巴瘤診斷和鑒別診斷有用的標記物。
產品圖片
Paraformaldehyde-fixed, paraffin embedded Human Spleen; Antigen retrieval by boiling in EDTA buffer (pH9.0) for 15 min; Antibody incubation with CD23 Monoclonal Antibody, Unconjugated(bsm-60453R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded (human tonsil); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD23) Monoclonal Antibody, Unconjugated (bsm-60453R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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