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Rabbit Anti-TIMP-2  antibody (bs-21340R)  
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產(chǎn)品編號 bs-21340R
英文名稱 Rabbit Anti-TIMP-2  antibody
中文名稱 金屬蛋白酶組織抑制因子-2抗體
別    名 Metalloproteinase inhibitor 2 precursor; Tissue inhibitor of metalloproteinases 2; Collagenase inhibitor; CSC 21K; CSC21K; TIMP2; TIMP 2; TIMP 2; TIMP metallopeptidase inhibitor 2; TIMP2_HUMAN; Metalloproteinase inhibitor 2; CSC-21K; TIMP-2.  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  生長因子和激素  合成與降解  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,Rat (predicted: Human,Rabbit,Pig,Sheep,Cow,Zebrafish,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 24kDa
細(xì)胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TIMP-2 : 31-130/220 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008].

Function:
: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.

Subunit:
: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.

Subcellular Location:
Secreted.

Post-translational modifications:
The activity of TIMP2 is dependent on the presence of disulfide bonds.

Similarity:
Belongs to the protease inhibitor I35 (TIMP) family.
Contains 1 NTR domain.

SWISS:
P16035

Gene ID:
7077

Database links:

Entrez Gene: 282093 Cow

Entrez Gene: 100135629 Guinea pig

Entrez Gene: 7077 Human

Entrez Gene: 21858 Mouse

Entrez Gene: 100008689 Rabbit

Entrez Gene: 29543 Rat

Omim: 188825 Human

SwissProt: P16368 Cow

SwissProt: Q9WUC6 Guinea pig

SwissProt: P16035 Human

SwissProt: P25785 Mouse

SwissProt: Q9TRZ7 Rabbit

SwissProt: P30121 Rat

Unigene: 633514 Human

Unigene: 206505 Mouse

Unigene: 10161 Rat



合成與降解(Synthesis and Degradation)
TIMP-2與TIMP-1一樣是基質(zhì)金屬蛋白酶的抑制酶,其功能與MMP相反,能抑制腫瘤細(xì)胞的浸潤和轉(zhuǎn)移,主要用于各種惡性腫瘤如乳腺癌等的研究。TIMP-2又稱為CSC-21K,是一種21-24kDa的糖蛋白,在多種組織細(xì)胞中表達(dá),它可以和MMPs家族成員以共價鍵方式形成復(fù)合物,從而發(fā)揮其抑制作用。在正常生理條件下,MMPs和TIMPs之間的平衡狀態(tài)是維持細(xì)胞外基質(zhì)正常狀態(tài)所必需的,一旦它們之間的比例失調(diào),就會造成一系列的病理狀態(tài)。
產(chǎn)品圖片
Sample: Lane 1: Testis (Mouse) Lysate at 40 ug Lane 2: Hippocampus (Mouse) Lysate at 40 ug Primary: Anti-TIMP-2 (bs-21340R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 22 kD Observed band size: 20 kD
Sample: Lane 1: Ovary (Rat) Lysate at 40 ug Lane 2: Testis (Rat) Lysate at 40 ug Primary: Anti-TIMP-2 (bs-21340R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 22 kD Observed band size: 22 kD
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