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Rabbit Anti-CD43  antibody (bs-20324R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號(hào) bs-20324R
英文名稱 Rabbit Anti-CD43  antibody
中文名稱 CD43抗體
別    名 LEUK_HUMAN; Leukosialin; SPN; GPL115; GALGP; GPL 115; Galactoglycoprotein (GALGP); Leukocyte sialoglycoprotein; Sialophorin; CD43 cytoplasmic tail; CD 43; CD43 antigen;   
研究領(lǐng)域 免疫學(xué)  干細(xì)胞  淋巴細(xì)胞  t-淋巴細(xì)胞  b-淋巴細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse,Rat
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 38kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD43: 101-200/400 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of serine and threonine residues, allowing extensive O-glycosylation, and has one potential N-glycosylation site, while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals. Different glycoforms of this protein have been described. In stimulated immune cells, proteolytic cleavage of the extracellular domain occurs in some cell types, releasing a soluble extracellular fragment. Defects in expression of this gene are associated with Wiskott-Aldrich syndrome. [provided by RefSeq, Sep 2017]

Function:
One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1. During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response.

Subunit:
Interacts with HIPK2 via the cytoplasmic domain. Interacts with RDX.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.

Post-translational modifications:
Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures.

SWISS:
P16150

Gene ID:
6693

Database links:

Entrez Gene: 6693 Human

Entrez Gene: 20737 Mouse

SwissProt: P16150 Human

SwissProt: P15702 Mouse



產(chǎn)品圖片
Sample: Lane 1: Mouse Spleen tissue lysates Lane 2: Mouse Thymus tissue lysates Lane 3: Rat Spleen tissue lysates Primary: Anti-CD43 (bs-20324R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 38 kDa Observed band size: 110 kDa
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