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Rabbit Anti-TMEPAI  antibody (bs-12668R)  
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產品編號 bs-12668R
英文名稱 Rabbit Anti-TMEPAI  antibody
中文名稱 跨膜前列腺雄激素誘導蛋白1抗體
別    名 PMEPA_HUMAN; PMEPA1; Prostate transmembrane protein, androgen induced 1; Solid tumor associated 1 protein; Solid tumor-associated 1 protein; STAG1; Transmembrane prostate androgen induced protein; Transmembrane prostate androgen-induced protein; Transmembrane, prostate androgen induced RNA.  
研究領域 腫瘤  細胞生物  信號轉導  生長因子和激素  跨膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Mouse (predicted: Rat,Sheep,Chicken)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 32kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TMEPAI: 21-120/287 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Function:
Involved in down-regulation of the androgen receptor (AR). Enhances ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Highest expression in prostate. Also expressed in ovary.

Similarity:
Belongs to the PMEPA1 family.

SWISS:
Q969W9

Gene ID:
56937

Database links:

Entrez Gene: 56937 Human

Omim: 606564 Human

SwissProt: Q969W9 Human

Unigene: 517155 Human



產品圖片
Sample: Uterus(Mouse) Lysate at 40 ug Primary: Anti-TMEPAI (bs-12668R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 32 kD Observed band size: 32 kD
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