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Rabbit Anti-USP52/Pan2  antibody (bs-21012R)  
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產品編號 bs-21012R
英文名稱 Rabbit Anti-USP52/Pan2  antibody
中文名稱 泛素特異性蛋白酶52抗體
別    名 hPan2; Inactive ubiquitin carboxyl terminal hydrolase 52; Inactive ubiquitin carboxyl-terminal hydrolase 52; KIAA0710; PAB dependent poly(A) specific ribonuclease subunit 2; PAB-dependent poly(A)-specific ribonuclease subunit 2; PABP dependent poly(A) nuclease 2; PAN 2; PAN2; PAN2 homolog PABP1 dependent poly A specific ribonuclease subunit; PAN2 poly(A) specific ribonuclease subunit homolog; PAN2 polyA specific ribonuclease subunit homolog; PAN2_HUMAN; Ubiquitin specific peptidase 52; Ubiquitin specific protease 52; USP 52; USP52.  
研究領域 細胞生物  發育生物學  轉錄調節因子  表觀遺傳學  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Rabbit)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 135kDa
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human USP52/Pan2: 641-740/1202 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Function:
Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein.

Subcellular Location:
Cytoplasm. Nucleus. Shuttles between nucleus and cytoplasm.

Similarity:
Belongs to the peptidase C19 family.
PAN2 subfamily.
Contains 1 exonuclease domain.

SWISS:
Q504Q3

Gene ID:
9924

Database links:

Entrez Gene: 9924 Human

Entrez Gene: 103135 Mouse

Entrez Gene: 408200 Rat

SwissProt: Q504Q3 Human

SwissProt: Q8BGF7 Mouse

SwissProt: Q6IE70 Rat

Unigene: 273397 Human

Unigene: 244183 Mouse

Unigene: 9091 Rat



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