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Rabbit Anti-SLC34A1  antibody (bs-19812R)  
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產品編號 bs-19812R
英文名稱 Rabbit Anti-SLC34A1  antibody
中文名稱 溶質載體家族蛋白34成員A1抗體
別    名 FRTS2; Na(+)-dependent phosphate cotransporter 2A; Na(+)/Pi cotransporter 2A; Na+-phosphate cotransporter type II; naPi-2a; NAPI-3; naPi2a; NAPI3; NPHLOP1; NPT2; NPTIIa; renal sodium-dependent phosphate transporter; renal sodium/phosphate transporter protein 2; SLC11; SLC17A2; SLC17A2, formerly; NPT2A_HUMAN; sodium-dependent phosphate transport protein 2A; sodium-phosphate transport protein 2A; sodium/phosphate co-transporter; sodium/phosphate cotransporter 2A; sodium/phosphate transporter 2, kidney; solute carrier family 17 (sodium phosphate), member 2; solute carrier family 17, member 2, formerly; solute carrier family 34 (sodium phosphate), member 1; solute carrier family 34 (type II sodium/phosphate.   
研究領域 細胞生物  信號轉導  轉運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Rat (predicted: Mouse,Rabbit,Pig,Sheep,Cat)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 69kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SLC34A1: 101-200/639 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

Function:
May be involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx.

Subunit:
Interacts via its C-terminal region with PDZK2 (By similarity). Interacts with SLC9A3R1.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Kidney and lung.

DISEASE:
The disease is caused by mutations affecting the gene represented in this entry. Disease description:A disease characterized by decreased renal phosphate absorption, renal phosphate wasting, hypophosphatemia, hyperphosphaturia, hypercalciuria, nephrolithiasis and osteoporosis.

Similarity:
Belongs to the SLC34A transporter family.

SWISS:
Q06495

Gene ID:
6569

Database links:

Entrez Gene: 282483 Cow

Entrez Gene: 100735387 Guinea pig

Entrez Gene: 100058397 Horse

Entrez Gene: 6569 Human

Entrez Gene: 20505 Mouse

Entrez Gene: 100155735 Pig

Entrez Gene: 733703 Pig

Entrez Gene: 100009392 Rabbit

Entrez Gene: 25548 Rat

Entrez Gene: 443505 Sheep

Omim: 182309 Human

SwissProt: Q06495 Human

SwissProt: Q60825 Mouse

SwissProt: Q28620 Rabbit

SwissProt: Q06496 Rat

SwissProt: O97704 Sheep

Unigene: 936 Human

Unigene: 276355 Mouse

Unigene: 92022 Rat



產品圖片
Tissue/cell: human kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-SLC34A1 Polyclonal Antibody, Unconjugated(bs-19812R) 1:600, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Tissue/cell: rat lung tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-SLC34A1 Polyclonal Antibody, Unconjugated(bs-19812R) 1:600, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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