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Rabbit Anti-SENP2  antibody (bs-19632R)  
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產(chǎn)品編號(hào) bs-19632R
英文名稱 Rabbit Anti-SENP2  antibody
中文名稱 泛素樣蛋白特異性蛋白酶2抗體
別    名 Axam2; DKFZp762A2316; KIAA1331; Senp2; SERP2; SENP2_HUMAN; Sentrin specific protease 2; Sentrin-specific protease 2; Sentrin/SUMO specific protease SENP2; Sentrin/SUMO-specific protease SENP2; SMT3 specific isopeptidase 2; SMT3-specific isopeptidase 2; Smt3ip2; SUMO1/sentrin/SMT3 specific peptidase 2.  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse (predicted: Human,Rat)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 68kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SENP2: 1-100/589 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]

Function:
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.

Subcellular Location:
Nucleus > nuclear pore complex. Nucleus membrane. Cytoplasm. Shuttles between cytoplasm and nucleus.

Post-translational modifications:
Polyubiquitinated; which leads to proteasomal degradation.

Similarity:
Belongs to the peptidase C48 family.

SWISS:
Q9HC62

Gene ID:
59343

Database links:

Entrez Gene: 59343 Human

Entrez Gene: 75826 Mouse

Entrez Gene: 78973 Rat

Omim: 608261 Human

SwissProt: Q9HC62 Human

SwissProt: Q91ZX6 Mouse

SwissProt: Q9EQE1 Rat

Unigene: 401388 Human

Unigene: 297431 Mouse

Unigene: 9367 Rat



產(chǎn)品圖片
Protein: lung(mouse) lysate at 40ug; Primary: rabbit Anti-SENP2(bs-19632R) at 1:300; Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 68 kD Observed band size: 63 kD
Protein: bone(mouse) lysate at 40ug; Primary: rabbit Anti-SENP2(bs-19632R) at 1:300; Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 68 kD Observed band size: 63 kD
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