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Rabbit Anti-TRAM2  antibody (bs-16566R)  
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產品編號 bs-16566R
英文名稱 Rabbit Anti-TRAM2  antibody
中文名稱 相關易位膜蛋白2抗體
別    名 C330003D03Rik; KIAA0057; MGC25725; OTTHUMP00000016607; TRAM like protein; Tram2; TRAM2_HUMAN; Translocating chain associating membrane protein 2; Translocating chain-associated membrane protein 2; Translocation associated membrane protein 2.  
研究領域 細胞生物  信號轉導  跨膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 43kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRAM2: 51-150/370 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]

Function:
Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding.

Subcellular Location:
Membrane.

Similarity:
Belongs to the TRAM family.
Contains 1 TLC (TRAM/LAG1/CLN8) domain.

SWISS:
Q15035

Gene ID:
9697

Database links:

Entrez Gene: 9697 Human

Entrez Gene: 617287 Cow

Entrez Gene: 474936 Dog

Entrez Gene: 100730382 Guinea pig

Entrez Gene: 100069225 Horse

Entrez Gene: 170829 Mouse

Entrez Gene: 100157796 Pig

Entrez Gene: 301296 Rat

Entrez Gene: 406344 Zebrafish

Omim: 608485 Human

SwissProt: Q15035 Human

SwissProt: Q924Z5 Mouse

Unigene: 520182 Human

Unigene: 185680 Mouse

Unigene: 273241 Mouse



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