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Rabbit Anti-FBXO3  antibody (bs-14676R)  
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產品編號 bs-14676R
英文名稱 Rabbit Anti-FBXO3  antibody
中文名稱 F-box蛋白家族FBXO3抗體
別    名 F Box G - Domain 3; F box only protein 3; F box protein 3; F box protein FBX3; F-box only protein 3; FBA; FBX3; FBX3_HUMAN; FBXO3.  
研究領域 細胞生物  信號轉導  轉錄調節因子  表觀遺傳學  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse (predicted: Human,Rat,Rabbit,Pig,Sheep,Dog,Horse)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 55kDa
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FBXO3: 1-100/471 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end. [provided by RefSeq, Jul 2008]

Function:
Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.

Subunit:
Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO3, SKP1, CUL1 and RBX1. Interacts with PML, interaction is direct and takes place either alone or within the SCF complex.

Subcellular Location:
Nucleus. Colocalizes with PML at the peripheries of nuclear bodies.

Similarity:
Contains 1 apaG domain.
Contains 1 F-box domain.

SWISS:
Q9UK99

Gene ID:
26273

Database links:

Entrez Gene: 26273 Human

Entrez Gene: 57443 Mouse

Entrez Gene: 690634 Rat

Omim: 609089 Human

SwissProt: Q9UK99 Human

SwissProt: Q9DC63 Mouse

SwissProt: D4ABP9 Rat

Unigene: 406787 Human

Unigene: 143768 Mouse

Unigene: 201745 Rat



產品圖片
Sample: Thymus (Mouse) Lysate at 40 ug Primary: Anti- FBXO3 (bs-14676R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 55 kD Observed band size: 55 kD
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