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Rabbit Anti-ECM29  antibody (bs-14486R)  
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產(chǎn)品編號 bs-14486R
英文名稱 Rabbit Anti-ECM29  antibody
中文名稱 ECM29蛋白抗體
別    名 ECM29 homolog, proteasome accessory protein; FLJ22036; ECM29_HUMAN; KIAA0368; KIAA1962; Proteasome associated protein ECM29 homolog; RP11-386D8.2.  
研究領(lǐng)域 細胞生物  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Horse)
產(chǎn)品應用 IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 204kDa
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ECM29: 1701-1845/1845 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 ECM29 is a 1,845 amino acid protein containing twenty-seven HEAT repeats. Localizing primarily to endoplasmic reticulum, ECM29 acts as an adapter or scaffolding protein, binding to the 26S proteasome, motor proteins, and other compartment specific proteins. The N-terminus of ECM29 binds endocytic proteins, including rabaptin, Rab11-FIP4, and VPS11, while the C-terminus binds myosins and kinesins. ECM29 may also play a role in endoplasmic reticulum (ER)-associated protein degradation (ERAD) in addition to other enhanced proteolysis.

Function:
ECM29 appears to be one of three proteins which associate significantly with proteasomes. ECM29 has been shown to enhance the stability of the proteasome. ECM29 deletion has been shown to produce 26S proteasomes which dissociated in the absence of ATP. It was thus suggested that ECM29 tethers the regulatory complex to the proteasome.

Subcellular Location:
Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Endosome. Cytoplasm ?cytoskeleton ?centrosome. Nucleus.

Similarity:
Contains 27 HEAT repeats.

SWISS:
Q5VYK3

Gene ID:
23392

Database links:

Entrez Gene: 23392 Human

Entrez Gene: 230249 Mouse

SwissProt: Q5VYK3 Human

SwissProt: Q6PDI5 Mouse

Unigene: 368255 Human



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