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Rabbit Anti-Cyclophilin E  antibody (bs-14138R)  
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產(chǎn)品編號(hào) bs-14138R
英文名稱 Rabbit Anti-Cyclophilin E  antibody
中文名稱 親環(huán)蛋白(親環(huán)素)E抗體
別    名 Ab1-210; Cyclophilin 33; Cyclophilin E; Cyclophilin-33; CYP 33; CYP33; EC 5.2.1.8; Peptidyl prolyl cis trans isomerase E; Peptidyl-prolyl cis-trans isomerase E; Peptidylprolyl isomerase E (cyclophilin E); Peptidylprolyl isomerase E; PPIase E; PPIE; PPIE_HUMAN; Rotamase E.  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  結(jié)合蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,Rat (predicted: Human,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 33kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cyclophilin E: 201-301/301 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]

Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in muscle- and brain-specific processes. May be involved in pre-mRNA splicing.

Subcellular Location:
Nucleus.

Tissue Specificity:
Found in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Similarity:
Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
Contains 1 PPIase cyclophilin-type domain.
Contains 1 RRM (RNA recognition motif) domain.

SWISS:
Q9UNP9

Gene ID:
10450

Database links:

Entrez Gene: 10450 Human

Entrez Gene: 787681 Cow

Entrez Gene: 56031 Mouse

Entrez Gene: 298508 Rat

Omim: 602435 Human

SwissProt: A4FV72 Cow

SwissProt: Q9UNP9 Human

SwissProt: Q9QZH3 Mouse

Unigene: 524690 Human

Unigene: 126873 Mouse

Unigene: 18887 Rat



產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded (mouse lung); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Cyclophilin E) Polyclonal Antibody, Unconjugated (bs-14138R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat lung); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Cyclophilin E) Polyclonal Antibody, Unconjugated (bs-14138R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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