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Rabbit Anti-CEP57  antibody (bs-13608R)  
~~~促銷代碼KT202411~~~
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產品編號 bs-13608R
英文名稱 Rabbit Anti-CEP57  antibody
中文名稱 睪丸特異性蛋白57抗體
別    名 Centrosomal protein 57kDa; Centrosomal protein of 57 kDa; Cep57; Cep57 protein; CEP57_HUMAN; FGF2 interacting protein; FGF2-interacting protein; KIAA0092; MVA2; PIG8; Proliferation inducing protein 8; Testis specific protein 57; Testis-specific protein 57; Translokin; TSP57.  
研究領域 細胞生物  發育生物學  干細胞  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 57kDa
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CEP57: 51-150/500 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 CEP57 (centrosomal protein 57kDa), also known as PIG8, TSP57 or Translokin, is a 500 amino acid protein that localizes to both the nucleus and the cytoplasm, specifically associating with microtubules at the centrosome. Expressed ubiquitously, CEP57 exists as a homodimer that functions to mediate the mitogenic activity and nuclear translocation of FGF-2, an internalized growth factor, thereby regulating FGF-2 signaling pathways. Additionally, CEP57 is thought to play a role in spermatogenesis, possibly via the indirect regulation of gene expression. Human CEP57 shares 88% sequence identity with its mouse and bovine orthologs, suggesting a highly conserved role between species. Multiple isoforms of CEP57 exist due to alternative splicing events.

Function:
Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Ubiquitous.

Similarity:
Belongs to the translokin family.

SWISS:
Q86XR8

Gene ID:
9702

Database links:

Entrez Gene: 9702 Human

Entrez Gene: 353245 Cow

Entrez Gene: 74360 Mouse

Entrez Gene: 315423 Rat

Omim: 607951 Human

SwissProt: Q865V0 Cow

SwissProt: Q86XR8 Human

SwissProt: Q8CEE0 Mouse

SwissProt: B4F7A7 Rat

Unigene: 101014 Human

Unigene: 157212 Mouse

Unigene: 94972 Rat



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