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Rabbit Anti-DLL1  antibody (bs-7345R)  
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產品編號 bs-7345R
英文名稱 Rabbit Anti-DLL1  antibody
中文名稱 Notch信號通路Delta樣配體1抗體
別    名 Delta (Drosophila) like 1; Delta; Delta like 1 (Drosophila); Delta like 1; Delta like 1 protein; Delta like protein 1; Delta like protein 1 precursor; Delta, Drosophila, homolog of 1; Delta-like protein 1; Delta1; DL1; DLL 1; Dll1; DLL1_HUMAN; Drosophila Delta homolog 1; H-Delta-1; OTTHUMP00000017690.  
研究領域 腫瘤  細胞生物  免疫學  干細胞  轉錄調節因子  淋巴細胞  b-淋巴細胞  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse (predicted: Human,Rat,Cow,Chicken)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 76kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DLL1: 1-100/723 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged-2 and Delta. While blocking the differentiation of progenitor cells into the B cell lineage, Delta promotes the emergence of a population of cells with T cell/NK-cell characteristics. Delta is a membrane protein expressed in heart, pancreas, brain and muscle during gastrulation and early organogenesis, and in adult heart and lung.

Function:
Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.

Subunit:
Interacts with Notch receptors.

Subcellular Location:
Membrane.

Tissue Specificity:
Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.

Post-translational modifications:
Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.

Similarity:
Contains 1 DSL domain.
Contains 8 EGF-like domains.

SWISS:
O00548

Gene ID:
28514

Database links:

Entrez Gene: 28514 Human

Entrez Gene: 13388 Mouse

Entrez Gene: 84010 Rat

Omim: 606582 Human

SwissProt: O00548 Human

SwissProt: Q61483 Mouse

SwissProt: P97677 Rat

Unigene: 379912 Human

Unigene: 4875 Mouse

Unigene: 10628 Rat



產品圖片
Sample:Heart (Mouse) Lysate at 40 ug Primary: Anti-DLL1(bs-7345R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 76kD Observed band size: 81kD
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