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Rabbit Anti-Sumo2+3  antibody (bs-7338R)  
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產品編號 bs-7338R
英文名稱 Rabbit Anti-Sumo2+3  antibody
中文名稱 泛素樣蛋白Sumo2/3抗體
別    名 Sumo 2 + Sumo 3; Sumo2/3; HSMT3; MGC117191; OTTHUMP00000115275; OTTHUMP00000115276; OTTHUMP00000115277; Sentrin 2; Small ubiquitin like modifier 2; Small ubiquitin like modifier protein 3; Small ubiquitin related modifier 2; Small ubiquitin related modifier 3; SMT3 A; SMT3 B; SMT3 H1; SMT3 H2; SMT3 homolog 1; SMT3 homolog 2; SMT3 homolog; SMT3 suppressor of mif two 3 homolog 1; SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); SMT3 suppressor of mif two 3 homolog 2; SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae); SMT3 suppressor of mif two 3 homolog 3; SMT3A; SMT3B; SMT3H1; SMT3H2; Sumo 2; Sumo 3; Sumo2; Sumo3; Suppressor of mif two 3 homolog 2; Suppressor of mif two 3 homolog 3; Ubiquitin like protein SMT3A; Ubiquitin like protein SMT3B; SUMO2_HUMAN; SUMO3_HUMAN.  
研究領域 細胞生物  神經生物學  細胞周期蛋白  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human (predicted: Mouse,Rat,Rabbit,Cow,Zebrafish,Chicken,Horse)
產品應用 Flow-Cyt=3ug/test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Sumo2+Sumo3: 21-95/95 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer’s disease.

Function:
SUMO proteins, such as Sumo 2 and Sumo 3, post-translationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. Sumo 2 and Sumo 3 are highly homologous, hence it is very difficult to produce antibodies which distinguish them.

Subunit:
Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains).

Subcellular Location:
Cytoplasmic (SUMO3) and Nuclear (SUMO2)

Tissue Specificity:
Broadly expressed.

Post-translational modifications:
Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4.
Cleavage of precursor form by SENP1 or SENP2 is necessary for function.

Similarity:
Belongs to the ubiquitin family. SUMO subfamily.
Contains 1 ubiquitin-like domain.

SWISS:
P61956

Gene ID:
6613

Database links:

Entrez Gene: 6612 Human

Entrez Gene: 6613 Human

Entrez Gene: 170930 Mouse

Entrez Gene: 20610 Mouse

Entrez Gene: 397044 Pig

Entrez Gene: 499417 Rat

Entrez Gene: 690244 Rat

Omim: 602231 Human

Omim: 603042 Human

SwissProt: P61955 Cow

SwissProt: P55854 Human

SwissProt: P61956 Human

SwissProt: P61957 Mouse

SwissProt: Q9Z172 Mouse

SwissProt: P61958 Pig

SwissProt: P61959 Rat

SwissProt: Q5XIF4 Rat



產品圖片
Blank control:A549. Primary Antibody (green line): Rabbit Anti-SUMO3 antibody (bs-7338R) Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-PE Dilution: 3μg /test. Protocol The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at-20℃. The cells were then incubated in 5% BSA to block non-specific protein-protein interactions for 30 min at at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
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