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Rabbit Anti-BOULE  antibody (bs-12880R)  
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產品編號 bs-12880R
英文名稱 Rabbit Anti-BOULE  antibody
中文名稱 精子成熟相關蛋白BOULE抗體
別    名 Bol (Drosophila boule homolog) like; Bol; Bol boule like; Bol, boule like (Drosophila); bol, boule-like (Drosophila); Boll; BOLL_HUMAN; BOULE; Boule like; BOULE, Drosophila, homolog of; Protein boule like; Protein boule-like; Putative uncharacterized protein BOLL.  
Specific References  (1)     |     bs-12880R has been referenced in 1 publications.
[IF=1.832] Li T et al. Histomorphological Comparisons and Expression Patterns of BOLL Gene in Sheep Testes at Different Development Stages.Animals (Basel). 2019 Mar 21;9(3).  WB&IHC ;  Sheep.  
研究領域 細胞生物  發育生物學  細胞分化  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Dog,Monkey)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 31kDa
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BOULE: 1-100/283 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Spermatogenesis represents the intricate developmental process of mitotic and meiotic cell divisions that ultimately leads to the production of haploid spermatozoa. BOULE, a member of the human deleted in azoospermia (DAZ) family, functions as a key conserved switch that regulates the progression of germ cells through meiosis in man. BOULE is an RNA-binding protein that regulates the expression of twine, a Cdc25 phosphatase, which promotes progression through meiosis. BOULE is expressed not only in the testis, but also in the nervous system, where it may play a role in neural communication. Mutations in the BOULE gene are be associated with male infertility, and the relative proportions of the three BOULE isoforms (B1, B2 and B3) may function as predictive markers for meiotic efficiency.

Function:
Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.

Subunit:
Interacts with DAZ1 and DAZL.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Testis specific. Not expressed in early embryos, primordial germ cells and spermatogonial cells. First expressed in the cytoplasm of spermatocytes and then persists through meiosis.

Similarity:
Belongs to the RRM DAZ family.
Contains 1 DAZ-like domain.
Contains 1 RRM (RNA recognition motif) domain.

SWISS:
Q8N9W6

Gene ID:
66037

Database links:

Entrez Gene: 527841 Cow

Entrez Gene: 66037 Human

Entrez Gene: 75388 Mouse

Entrez Gene: 501143 Rat

Omim: 606165 Human

SwissProt: Q8N9W6 Human

SwissProt: Q924M5 Mouse



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