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Rabbit Anti-SPPL2B  antibody (bs-11682R)  
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產品編號 bs-11682R
英文名稱 Rabbit Anti-SPPL2B  antibody
中文名稱 膜內蛋白酶4抗體
別    名 IMP4; Signal peptide peptidase-like 2B; Intramembrane protease 4; Protein SPP-like 2B; SPPL2B; SPP2B_HUMAN.  
研究領域 細胞生物  神經生物學  信號轉導  細胞粘附分子  泛素  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Dog,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 65kDa
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPPL2B: 55-135/592 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
The SPPLs are a group of aspartic proteases that are responsible for proteolysis of type II membrane-anchored signalling factors. SPPL2b, unlike other SPPL family members is found in endosomes/lysosomes, and not the endoplasmic reticulum, and has a role in catalysing intramembrane cleavage of tumour necrosis factor alpha (TNFalpha).

Subunit:
Monomer. Homodimer. Interacts with ITM2B and TNF.

Subcellular Location:
Membrane; multi-pass membrane protein of endosomes/lysosomes.

Tissue Specificity:
Expressed predominantly in adrenal cortex and mammary gland.

Post-translational modifications:
Glycosylated.

Similarity:
Belongs to the peptidase A22B family.
Contains 1 PA (protease associated) domain.

SWISS:
Q8TCT7

Gene ID:
56928

Database links:

Entrez Gene: 56928 Human

SwissProt: Q8TCT7 Human

Unigene: 330742 Human



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