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Rabbit Anti-EVA1  antibody (bs-11080R)  
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產(chǎn)品編號 bs-11080R
英文名稱 Rabbit Anti-EVA1  antibody
中文名稱 髓鞘蛋白P0樣蛋白2抗體
別    名 Epithelial V like antigen 1; epithelial V-like antigen; EVA; EVA1; MPZL2; MPZL2 myelin protein zero like 2; myelin protein zero-like 2; Myelin protein zero like protein 2; MPZL2_HUMAN.  
Specific References  (1)     |     bs-11080R has been referenced in 1 publications.
[IF=8.469] Wang, Xiaosong. et al. Serum-derived extracellular vesicles facilitate temozolomide resistance in glioblastoma through a HOTAIR-dependent mechanism. CELL DEATH DIS. 2022 Apr;13(4):1-11  WB ;  Human.  
研究領域 神經(jīng)生物學  細胞粘附分子  細胞骨架  細胞外基質  跨膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產(chǎn)品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 22kDa
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MPZL2/EVA1: 61-160/215 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Mediates homophilic cell-cell adhesion.

Subcellular Location:
Cell Membrane; Single-pass type I membrane protein, cytoskeleton

Tissue Specificity:
Expressed in thymocytes and thymic stromal cells; expression elevated in some T-cell leukemias.

Similarity:
Belongs to the myelin P0 protein family.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

SWISS:
O60487

Gene ID:
10205

Database links:

Entrez Gene: 10205 Human

Omim: 604873 Human

SwissProt: O60487 Human

Unigene: 116651 Human



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