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Rabbit Anti-EDRF1  antibody (bs-9737R)  
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產(chǎn)品編號 bs-9737R
英文名稱 Rabbit Anti-EDRF1  antibody
中文名稱 紅細胞分化相關(guān)因子1抗體
別    名 C10orf137 protein; Chromosome 10 open reading frame 137; EDRF1; Erythroid differentiation related factor 1; EDRF1_HUMAN.  
研究領(lǐng)域 細胞生物  信號轉(zhuǎn)導(dǎo)  干細胞  細胞周期蛋白  細胞分化  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 139kDa
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Human EDRF1/C10orf137: 101-200/1238 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The tetratricopeptide repeat (TPR) motif is a degenerate, 34 amino acid sequence found in many proteins and acts to mediate protein-protein interactions in various pathways. At the sequence level, there can be up to 16 tandem TPR repeats, each of which has a helix-turn-helix shape that stacks on other TPR repeats to achieve ligand binding specificity. EDRF1 (erythroid differentiation-related factor 1), also known as C10orf137 (chromosome 10 open reading frame 137), is a 1,238 amino acid protein containing two TPR repeats. Localizing to nucleus, EDRF1 is involved in transcriptional activation of globin genes by regulating DNA-binding activity of GATA-1 transcription factor. EDRF1 may also play an important role in organ development and histological differentiation. EDRF1 exists as four alternatively spliced isoforms and is encoded by a gene mapping to human chromosome 10q26.13.

Function:
Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene.

Subcellular Location:
Nucleus

Similarity:
Contains 2 TPR repeats.

SWISS:
Q3B7T1

Gene ID:
26098

Database links:

Entrez Gene: 26098 Human

SwissProt: Q3B7T1 Human



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