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Rabbit Anti-EML3  antibody (bs-9731R)  
~~~促銷代碼KT202411~~~
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說明書: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產品編號 bs-9731R
英文名稱 Rabbit Anti-EML3  antibody
中文名稱 微管相關蛋白樣蛋白3抗體
別    名 Echinoderm microtubule associated protein like 3; ELP 95; EMAP 3; EMAP3; EMAP-3; EML 3; EML3; EML-3; FLJ 35827; MGC 111422; EMAL3_HUMAN.  
研究領域 細胞生物  細胞周期蛋白  細胞分化  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Rabbit)
產品應用 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 95kDa
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EML3: 451-550/896 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 At the onset of mitosis, assembly of the mitotic spindle requires a global change in the activity of microtubule-binding proteins. EML3 (Echinoderm microtubule-associated protein-like 3) is a 896 amino acid protein that likely modifies microtubule dynamics by making them longer. Through colocalization with spindle microtubules during mitosis, EML3 plays a role in correct metaphase chromosome alignment. EML3 contains a nuclear localization signal and a microtubule-binding domain. The gene encoding EML3 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.

Function:
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity).

Subcellular Location:
Cytoplasmic

Similarity:
Belongs to the WD repeat EMAP family.
Contains 9 WD repeats.

SWISS:
Q32P44

Gene ID:
256364

Database links:

Entrez Gene: 256364 Human

Entrez Gene: 225898 Mouse

Entrez Gene: 293723 Rat

SwissProt: Q32P44 Human

SwissProt: Q8VC03 Mouse



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