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Rabbit Anti-CASC5  antibody (bs-5959R)  
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產品編號 bs-5959R
英文名稱 Rabbit Anti-CASC5  antibody
中文名稱 腫瘤易感性候選基因5抗體
別    名 Protein D40/AF15q14; AF15Q14; ALL1 fused gene from chromosome 15q14; Blinkin bub linking kinetochore protein; Cancer susceptibility candidate 5; Cancer susceptibility candidate gene 5 protein; Cancer/testis antigen 29; CT29; D40; hKNL 1; hSpc105; KIAA1570; Kinetochore null 1 homolog; Kinetochore null protein 1; KNL1; CASC5_HUMAN.  
Specific References  (1)     |     bs-5959R has been referenced in 1 publications.
[IF=0] Lu, Zhimin, and Alfred WK Yung. "BIOMARKERS FOR CANCER CHARACTERIZATION AND TREATMENT." U.S. Patent No. 20,150,073,033. 12 Mar. 2015.  IP ;  
研究領域 腫瘤  細胞生物  免疫學  干細胞  細胞周期蛋白  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Mouse (predicted: Rat,Rabbit,Cow,Dog,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 265kDa
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CASC5: 2251-2342/2342 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Four known isoforms exist.

Function:
Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.

Subunit:
Interacts with DSN1, MIS12, BUB1, BUB1B, NSL1 and ZWINT.

Subcellular Location:
Nucleus. Chromosome, centromere, kinetochore.

Tissue Specificity:
Highly expressed in testis, where it is localized in germ cells, in particular in spermatocytes and in the pre-acrosome of round spermatids. Detected in the acrosome of ejaculated spermatozoa. Detected in adult thymus, bone marrow, colon, small intestine, appendix and placenta, and in fetal liver and thymus.

DISEASE:
Note=A chromosomal aberration involving CASC5 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with MLL/HRX. May give rise to a MLL-CASC5 fusion protein.

SWISS:
Q8NG31

Gene ID:
57082

Database links:

Entrez Gene: 57082 Human

Entrez Gene: 76464 Mouse

Omim: 609173 Human

SwissProt: Q8NG31 Human

SwissProt: Q66JQ7 Mouse



產品圖片
Sample: K562(Human) Cell Lysate at 30 ug Primary: Anti- CASC5 (bs-5959R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 265 kD Observed band size: 265 kD
Paraformaldehyde-fixed, paraffin embedded (mouse testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CASC5) Polyclonal Antibody, Unconjugated (bs-5959R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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