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Rabbit Anti-ADAM19  antibody (bs-5850R)  
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產(chǎn)品編號 bs-5850R
英文名稱 Rabbit Anti-ADAM19  antibody
中文名稱 去整合素樣金屬蛋白酶19抗體
別    名 A disintegrin and metalloproteinase domain 19 (meltrin beta); A disintegrin and metalloproteinase domain 19; ADAM 19; ADAM metallopeptidase domain 19; Disintegrin and metalloproteinase domain containing protein 19; FKSG 34; FKSG34; MADDAM; Meltrin beta; ADA19_HUMAN; Metalloprotease and disintegrin dentritic antigen marker; MLTN B; MLTNB.   
Specific References  (2)     |     bs-5850R has been referenced in 2 publications.
[IF=1.655] Moe Endo et al. Increased soluble (pro) renin receptor protein by autophagy inhibition in cultured cancer cells. Genes Cells . 2020 Jul;25(7):483-497.  ICC,WB ;  human.  
[IF=1.655] Endo M et al. Increased soluble (pro)renin receptor protein by autophagy inhibition in cultured cancer cells. Genes Cells. 2020 Jul;25(7):483-497.  WB&ICC ;  Human.  
研究領域 細胞生物  免疫學  信號轉導  細胞骨架  細胞外基質  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human (predicted: Mouse,Rat,Pig)
產(chǎn)品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 82kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ADAM19: 251-350/955 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013].

Function:
Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).

Subunit:
Interacts with SH3PXD2A.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed in many normal organ tissues and several cancer cell lines.

Post-translational modifications:
The precursor is cleaved by a furin endopeptidase (By similarity).

Similarity:
Contains 1 disintegrin domain.
Contains 1 EGF-like domain.
Contains 1 peptidase M12B domain.

SWISS:
Q9H013

Gene ID:
8728

Database links:

Entrez Gene: 8728 Human

Entrez Gene: 11492 Mouse

Entrez Gene: 303068 Rat

Omim: 603640 Human

SwissProt: Q9H013 Human

SwissProt: O35674 Mouse

SwissProt: Q14BL7 Mouse

SwissProt: Q80UF6 Mouse

Unigene: 89940 Mouse



細胞外基質蛋白
產(chǎn)品圖片
Sample: U251(Human) Cell Lysate at 30 ug Primary: Anti- ADAM19 (bs-5850R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 82 kD Observed band size: 82 kD
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