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Rabbit Anti-FABP4  antibody (bs-4059R)  
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產品編號 bs-4059R
英文名稱 Rabbit Anti-FABP4  antibody
中文名稱 脂肪細胞型脂肪酸結合蛋白抗體
別    名 adipocyte; 3T3-L1 lipid-binding protein; 422/aP2; A FABP; A-FABP; Adipocyte lipid binding protein; Adipocyte lipid-binding protein; Adipocyte protein AP2; Adipocyte-type fatty acid-binding protein; AFABP; ALBPv ALBP/Ap2; aP2; FABP; FABP4_HUMAN; Fatty acid binding protein 4 adipocyte; Fatty acid binding protein 4; Fatty acid binding protein adipocyte; Fatty acid-binding protein 4; Fatty acid-binding protein; Lbpl; Myelin P2 protein homolog; P15v P2 adipocyte protein; Protein 422.   
Specific References  (4)     |     bs-4059R has been referenced in 4 publications.
[IF=27.287] Clair Crewe. et al. Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes. Cell Metab. 2021 Sep;33:1853  FC ;  Mouse.  
[IF=3.79] Claycombe, Kate J., et al. "Decreased beige adipocyte number and mitochondrial respiration coincide with increased histone methyl transferase (9Ga) and reduced FGF21 gene expression in Sprague Dawley rats fed prenatal low protein and postnatal high fat diets." The Journal of Nutritional Biochemistry (2016).  FCM ;  Rat.  
[IF=3.123] Ferrante et al. Adipocyte-derived exosomal miRNAs: a novel mechanism for obesity-related disease. (2015) Pediatr.Res. 77:447-54  FCM ;  Human.  
[IF=1.399] Haodong Liu. et al. miR‐340‐5p inhibits sheep adipocyte differentiation by targeting ATF7. Anim Sci J. 2020 Jan;91(1):e13462  WB ;  Sheep.  
研究領域 腫瘤  免疫學  轉錄調節因子  結合蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat (predicted: Human,Mouse,Rabbit,Sheep,Cow,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 14kDa
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FABP4: 61-132/132 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq].

Function:
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.

Subunit:
Monomer. Homodimer. Interacts with PPARG.

Subcellular Location:
Cytoplasm. Nucleus. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export.

Similarity:
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

SWISS:
P15090

Gene ID:
2167

Database links:

Entrez Gene: 2167 Human

Entrez Gene: 11770 Mouse

Entrez Gene: 79451 Rat

Omim: 600434 Human

SwissProt: P15090 Human

SwissProt: P04117 Mouse

SwissProt: P70623 Rat

Unigene: 391561 Human

Unigene: 582 Mouse

Unigene: 4258 Rat



產品圖片
Paraformaldehyde-fixed, paraffin embedded (Rat breast); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (FABP4) Polyclonal Antibody, Unconjugated (bs-4059R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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