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Rabbit Anti-G protein beta 1  antibody (bs-3941R)  
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產(chǎn)品編號(hào) bs-3941R
英文名稱 Rabbit Anti-G protein beta 1  antibody
中文名稱 G蛋白β1抗體/鳥(niǎo)嘌呤核苷酸結(jié)合蛋白β亞基1
別    名 Beta subunit signal transducing proteins GS/GI; G protein beta 1 subunit; GBB1; Guanine nucleotide binding protein beta 1 subunit; Transducin beta chain 1; GBB1_HUMAN.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  結(jié)合蛋白  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human (predicted: Mouse,Rat,Pig,Sheep,Cow,Chicken)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 37kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human G protein beta 1: 21-120/340 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Heterotrimeric guanine nucleotide binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. GNB1 is a beta subunit. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Subunit:
G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. The heterodimer formed by GNB1 and GNG2 interacts with PTH1R (via C-terminus).

Post-translational modifications:
Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP (By similarity).

Similarity:
Belongs to the WD repeat G protein beta family.
Contains 7 WD repeats.

SWISS:
P62873

Gene ID:
2782

Database links:

Entrez Gene: 2782 Human

Entrez Gene: 14688 Mouse

Entrez Gene: 24400 Rat

Omim: 139380 Human

SwissProt: P62871 Cow

SwissProt: P62873 Human

SwissProt: P62874 Mouse

SwissProt: P54311 Rat

SwissProt: P79959 Xenopus laevis

Unigene: 430425 Human

Unigene: 2344 Mouse

Unigene: 126047 Rat



產(chǎn)品圖片
Sample: Hela(Human) Cell Lysate at 30 ug Primary: Anti- G protein beta 1 (bs-3941R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 37 kD Observed band size: 37 kD
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