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Rabbit Anti-GDF15  antibody (bs-3818R)  
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產品編號 bs-3818R
英文名稱 Rabbit Anti-GDF15  antibody
中文名稱 生長分化因子15/巨嗜細胞抑制因子1抗體
別    名 GDF 15; GDF-15; GDF15_HUMAN; Growth differentiation factor 15; Growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC 1; Mic-1; MIC1; NAG 1; NAG-1; NAG1; NRG 1; NRG-1; NRG1; NSAID (nonsteroidal anti inflammatory drug) activated protein 1; NSAID; NSAID regulated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PDF; PLAB; Placental bone morphogenetic protein; Placental bone morphogenic protein; Placental TGF beta; Placental TGF-beta; Prostate differentiation factor; PTGF beta; PTGFB.   
Specific References  (9)     |     bs-3818R has been referenced in 9 publications.
[IF=7.561] Huan Li. et al. The Clinical Value of GDF15 and Its Prospective Mechanism in Sepsis. Front Immunol. 2021; 12: 710977  WB ;  human.  
[IF=6.429] Sugimoto Mitsuru. et al. Clinical usefulness and acceleratory effect of macrophage inhibitory cytokine-1 on biliary tract cancer: an experimental biomarker analysis. CANCER CELL INT. 2022 Dec;22(1):1-15  IHC ;  Human.  
[IF=5.29] Ueno, Koji, et al. "Increased plasma VEGF levels following ischemic preconditioning are associated with downregulation of miRNA-762 and miR-3072-5p." Scientific Reports 6 (2016): 36758.  WB ;  Mouse.  
[IF=4.736] Xu Guanlan. et al. Deletion of Gdf15 Reduces ER Stress-induced Beta-cell Apoptosis and Diabetes. ENDOCRINOLOGY. 2022 May;163(5):  WB ;  Mouse.  
[IF=4.6] Figueiredo, Jose-Luiz, et al. "Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E–Deficient Mice with Chronic Renal Disease." The American Journal of Pathology (2015).  IHC-F ;  Mouse.  
[IF=4.447] Juan Zhang. et al. DHODH inhibition modulates glucose metabolism, circulating GDF15 and improves metabolic balance. Iscience. 2021 May;:102494  
[IF=3.269] Mengxue Zhang. et al. Identification and validation of potential novel biomarkers for oral squamous cell carcinoma. Bioengineered. 2021;12(1):8845-8862  IF,IHC ;  Human,Mouse.  
[IF=1.89] Li, Yun-Long, et al. "Downregulation of growth differentiation factor-15 in trichostatin A-induced apoptosis could play a role in progression of gastric cancer." International Journal of Clinical and Experimental Pathology 8.7 (2015): 8136.  WB ;  Human.  
[IF=1.42] Ruan, Wei-Min, et al. "Differential expression of glycoprotein non-metastatic melanoma protein B (GPNMB) involved in trichostatin A-induced apoptosis in gastric cancer." International journal of clinical and experimental medicine 7.12 (2014): 4857-4866.  IHC-P ;  Human.  
研究領域 心血管  細胞生物  信號轉導  細胞周期蛋白  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Mouse,Rat
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
細胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GDF-15: 221-308/308 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Growth differentiation factor 15 (GDF15) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It has been implicated in a variety of functions directly related to tumorigenicity including antiproliferative and pro-apoptotic effects. BMP proteins are secreted growth factors that are characterized by seven conserved cysteine residues. In general, they are regulators of cell growth and differentiation in both embryonic and adult tissues. GDF15 is an important downstream mediator of DNA damage signaling and a transcriptional target of p53.

Subcellular Location:
Secreted.

Tissue Specificity:
Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney.

Similarity:
Belongs to the TGF-beta family.

SWISS:
Q99988

Gene ID:
9518

Database links:

Entrez Gene: 9518 Human

Entrez Gene: 23886 Mouse

Entrez Gene: 29455 Rat

Omim: 605312 Human

SwissProt: Q99988 Human

SwissProt: Q9Z0J7 Mouse

SwissProt: Q9Z0J6 Rat

Unigene: 616962 Human

Unigene: 31325 Mouse

Unigene: 44228 Rat



生長分化因子15(GDF15)是骨形態發生蛋白(BMP)和轉化生長因子-β超家族成員。GDF-15又叫巨噬細胞抑制因子(macrophage inhibiting cytokine,MIC)-1、胎盤轉化生長因子 (placental transformation growth factor,PTGF)-β、前列腺衍生因子(prostate derived factor,PDF)和胎盤骨形態發生蛋白(placental bone morphogeneticprotein,PLAB)。
有學者認為:GDF-15在腫瘤發展的不同階段發揮著不同的生物學作用;隨著腫瘤的發生發展,GDF-15可能表達不同形式的蛋白,在腫瘤發生的早期階段可能發揮抑瘤作用,而在腫瘤發展的后期階段發揮促瘤作用。
產品圖片
Sample: Lane 1: Urinary bladder (Mouse) Lysate at 40 ug Lane 2: Large intestine (Mouse) Lysate at 40 ug Lane 3: Urinary bladder (Rat) Lysate at 40 ug Lane 4: Large intestine (Rat) Lysate at 40 ug Lane 5: HT1080 (Human) cell Lysate at 40 ug Lane 6: HepG2 (Human) cell Lysate at 40 ug Lane 7: K562 (Human) cell Lysate at 40 ug Lane 8: A549 (Human) cell Lysate at 40 ug Primary: Anti-GDF15 (bs-3818R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 35 kD Observed band size: 35 kD
Paraformaldehyde-fixed, paraffin embedded (Mouse placenta); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (GDF15) Polyclonal Antibody, Unconjugated (bs-3818R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining.
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