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Rabbit Anti-PIN1  antibody (bs-3541R)  
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產品編號 bs-3541R
英文名稱 Rabbit Anti-PIN1  antibody
中文名稱 肽基脯氨酞順反異構酶Pinl抗體
別    名 DOD; NIMA interacting 1; Peptidyl prolyl cis trans isomerase NIMA interacting 1; Peptidyl prolyl cis/trans isomerase NIMA interacting; Pin 1; PPIase Pin1; Prolyl isomerase; Protein (peptidylprolyl cis/trans isomerase) NIMA interacting 1; Protein NIMA interacting 1; Rotamase Pin1; UBL 5; UBL5; PIN1_HUMAN.  
研究領域 細胞生物  神經生物學  細胞周期蛋白  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Mouse,Rat (predicted: Pig,Sheep,Cow,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 18kDa
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Pin1: 56-163/163 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds.
Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.

Function:
Essential PPIase that regulates mitosis presumably byinteracting with NIMA and attenuating its mitosis-promotingactivity. Displays a preference for an acidic residue N-terminal tothe isomerized proline bond. Catalyzes pSer/Thr-Pro cis/transisomerizations. Down-regulates kinase activity of BTK. Cantransactivate multiple oncogenes and induce centrosomeamplification, chromosome instability and cell transformation.Required for the efficient dephosphorylation and recycling of RAF1after mitogen activation.

Subunit:
Interacts with STIL. Interacts withKIF20B. Interacts with NEK6. Interacts (via WW domain) with PRKX.Interacts with BTK. Interacts (via PpiC domain) with DAPK1.Interacts with the phosphorylated form of RAF1. Interacts (via WWdomain) with ATCAY; upon NGF stimulation.

Subcellular Location:
Nucleus. Nucleus speckle. Cytoplasm.Note=Co-localizes with NEK6 in the nucleus. Mainly localized in thenucleus but phosphorylation at Ser-71 by DAPK1 results ininhibition of its nuclear localization.

Tissue Specificity:
The phosphorylated form at Ser-71 is expressedin normal breast tissue cells but not in breast cancer cells.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.Phosphorylation at Ser-71 by DAPK1 results in inhibition of itscatalytic activity, nuclear localization, and its ability to inducecentrosome amplification, chromosome instability and celltransformation.

Similarity:
Contains 1 PpiC domain.
Contains 1 WW domain.

SWISS:
Q13526

Gene ID:
5300

Database links:

Entrez Gene: 5300 Human

Entrez Gene: 23988 Mouse

Entrez Gene: 298696 Rat

Omim: 601052 Human

SwissProt: Q13526 Human

SwissProt: Q9QUR7 Mouse

Unigene: 465849 Human

Unigene: 7906 Mouse

Unigene: 6291 Rat



肽基脯氨酞順反異構酶Pinl,是調節細胞有絲分裂相關蛋白酶,對細胞周期運行起著非常重要的調控作用。近年來研究表明,肽基脯氨酞順反異構酶Pinl在多種腫瘤中過表達,是多個致癌信號通路的關鍵效應分子,可加強和催化多種致癌信號,使其無限放大,最終引起細胞轉化和增殖失控。因次,肽基脯氨酞順反異構酶Pinl越來越引起人們關注,被稱為腫瘤發生發展的催化分子。 近來該蛋白用于老年癡呆研究的也日漸增多。
產品圖片
Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PIN1) Polyclonal Antibody, Unconjugated (bs-3541R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat lung); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PIN1) Polyclonal Antibody, Unconjugated (bs-3541R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (human breast carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PIN1) Polyclonal Antibody, Unconjugated (bs-3541R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PIN1) Polyclonal Antibody, Unconjugated (bs-3541R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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