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Rabbit Anti-SPHK1  antibody (bs-2652R)  
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產(chǎn)品編號 bs-2652R
英文名稱 Rabbit Anti-SPHK1  antibody
中文名稱 鞘氨醇激酶1抗體
別    名 sphingosine kinase 1; SK 1; SK1; SPHK 1; SPHK; SPK; SPK 1; SPK1; Sphk1; SPHK1_HUMAN.  
Specific References  (9)     |     bs-2652R has been referenced in 9 publications.
[IF=11.743] Harlé Guillaume. et al. Macroautophagy in lymphatic endothelial cells inhibits T cell–mediated autoimmunity. J Exp Med. 2021 Jun;218(6):e20201776.  WB ;  Mouse.  
[IF=6.208] Christopher D. Carlucci. et al. Resveratrol Protects against Skin Inflammation through Inhibition of Mast Cell, Sphingosine Kinase-1, Stat3 and NF-κB p65 Signaling Activation in Mice. INT J MOL SCI. 2023 Jan;24(7):6707  WB ;  Mouse.  
[IF=4.29] Tran, Hai B., et al. "Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720." Journal of Leukocyte Biology (2016): jlb-3A1015.  Human.  
[IF=3.612] Hai B. Tran. et al. Dysregulated zinc and sphingosine-1-phosphate signaling in pulmonary hypertension: Potential effects by targeting of bone morphogenetic protein receptor type 2 in pulmonary microvessels. 2021 Aug 15  IF ;  Rat.  
[IF=3.53] Tani, Kohsuke, Keiji Tabuchi, and Akira Hara. "Hair Cell Loss Induced by Sphingosine and a Sphingosine Kinase Inhibitor in the Rat Cochlea."Neurotoxicity research 29.1 (2016): 35-46.  WB, IF(ICC) ;  Rat.  
[IF=2.89] Tran, Hai B., et al. "Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD." PloS one 12.11 (2017): e0179577.  IF(ICC) ;  Human.  
[IF=2.822] Zhang,et al.The Role of Tumor-Associated Ingredients in Serum on Antitumor Immunity.(2017) Drug Design Development and Therapy. 1:.  ELISA ;  Mouse.  
[IF=2.8] Tran H et al. Enhanced inflammasome activation and reduced sphingosine-1 phosphate S1P signalling in a respiratory mucoobstructive disease model. J Inflamm (Lond) . 2020 Apr 21;17:16.  IF ;  mouse.  
[IF=2.014] Li YAO. et al. Osthole attenuates pulmonary arterial hypertension by the regulation of sphingosine 1-phosphate in rats. Chin J Nat Medicines. 2020 Apr;18:308  WB ;  Rat.  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  激酶和磷酸酶  細(xì)胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,Rat (predicted: Human,Rabbit,Cow,Dog)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPHK1: 1-100/384 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Function:
Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra-and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.

Tissue Specificity:
Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle.

Similarity:
Contains 1 DAGKc domain.

SWISS:
Q9NYA1

Gene ID:
8877

Database links:

Entrez Gene: 8877 Human

Entrez Gene: 20698 Mouse

Entrez Gene: 170897 Rat

Omim: 603730 Human

SwissProt: Q9NYA1 Human

SwissProt: Q8CI15 Mouse

SwissProt: Q91V26 Rat

Unigene: 68061 Human

Unigene: 20944 Mouse

Unigene: 18522 Rat



SPHK1參與鞘氨醇代謝、G蛋白偶聯(lián)受體蛋白信號轉(zhuǎn)導(dǎo)途徑,有抗細(xì)胞凋亡的作用,可被蛋白激酶C激活,參與細(xì)胞內(nèi)信號轉(zhuǎn)導(dǎo)級聯(lián)、鈣介導(dǎo)信號轉(zhuǎn)導(dǎo)、調(diào)控細(xì)胞生長遷移、調(diào)控血管生成及成纖維細(xì)胞增殖。
產(chǎn)品圖片
Sample: Heart (Mouse) Lysate at 30 ug Primary: Anti- SPHK1 (bs-2652R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kD Observed band size: 52kD
Sample: Lane 1: Mouse Pancreas tissue lysates Lane 2: Mouse Lung tissue lysates Lane 3: Rat Kidney tissue lysates Primary: Anti-SPHK1 (bs-2652R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42-52 kDa Observed band size: 50 kDa
Paraformaldehyde-fixed, paraffin embedded (mouse brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SPHK1) Polyclonal Antibody, Unconjugated (bs-2652R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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