| 產(chǎn)品編號(hào) | bs-2596R |
| 英文名稱 | Rabbit Anti-CD35 antibody |
| 中文名稱 | Ⅰ型補(bǔ)體受體（C3b/C4b受體）抗體 |
| 別 名 | C3 binding protein; C3b/C4b receptor; C3BR; C4BR; CD 35; CD35; CD35 antigen; complement component (3b/4b) receptor 1 (Knops blood group); complement component (3b/4b) receptor 1 including Knops blood group system; Complement component receptor 1; Complement receptor 1; Complement receptor type 1; CR 1; CR1; CR1_HUMAN; KN; Knops blood group antigen. |
| 研究領(lǐng)域 | 免疫學(xué) 細(xì)胞膜受體 淋巴細(xì)胞 t-淋巴細(xì)胞 b-淋巴細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,Flow-Cyt=1μg /test,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 274kDa |
| 檢測分子量 | 160, 190, 220, and 250 |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CR1: 251-350/2039 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. [provided by RefSeq, May 2020] Function: Mediates cellular binding of particles and immune complexes that have activated complement. Subunit: Monomer. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. Similarity: Belongs to the receptors of complement activation (RCA) family. Contains 30 Sushi (CCP/SCR) domains. SWISS: P17927 Gene ID: 1378 Database links: Entrez Gene: 1378 Human Omim: 120620 Human SwissProt: P17927 Human Unigene: 334019 Human CD35廣泛分布于紅細(xì)胞、粒細(xì)胞、單核細(xì)胞、肥大細(xì)胞、濾泡樹突狀細(xì)胞、腎小球足突細(xì)胞、B細(xì)胞及部分CD4+T細(xì)胞表面.CD35抗原又稱為CR1或者C3b/C4b R，是一種分子量160-250kDa的C3b/C4b補(bǔ)體結(jié)合跨膜蛋白，主要用于濾泡樹突狀細(xì)胞標(biāo)記和濾泡樹突狀細(xì)胞瘤的診斷。 |
| 產(chǎn)品圖片 |
Blank control(blue): U937 (fixed with 2% paraformaldehyde (10 min)). Primary Antibody:Rabbit Anti-Dopamine Transporter antibody(bs-2596R), Dilution: 0.2μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
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