產(chǎn)品編號(hào) | bs-2490R |
英文名稱 | Rabbit Anti-CD23 antibody |
中文名稱 | CD23/FcεRII抗體 |
別 名 | Fc EpsilonR II; FcεRII; Blast 2; Blast2; C type lectin domain family 4 member J; C-type lectin domain family 4, member J; CD 23; CD 23A; CD23 antigen; CD23A; CLEC 4J; CLEC4J; Fc epsilon RII; Fc fragment of IgE low affinity II receptor for; Fc fragment of IgE, low affinity II, receptor for (CD23); Fc of IgE, low affinity II, receptor for (CD23); Fc receptor IgE low affinity II alpha polypeptide; Fc receptor, IgE, low affinity II, alpha polypeptide, isoform CRA_a; FCE 2; FCE2; FCER 2; FCER2; FCER2A; IgE binding factor; IgE receptor lymphocyte; IgE-binding factor; IGEBF; Immunoglobulin E binding factor; Immunoglobulin E receptor, low affinity II; Low affinity immunoglobulin epsilon Fc receptor; Low affinity immunoglobulin epsilon Fc receptor membrane bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form; Ly-42; Ly42; Lymphocyte antigen CD23; Lymphocyte IgE receptor; MGC93219. |
研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 干細(xì)胞 細(xì)胞類型標(biāo)志物 淋巴細(xì)胞 t-淋巴細(xì)胞 |
抗體來源 | Rabbit |
克隆類型 | Polyclonal |
交叉反應(yīng) | Human,Mouse (predicted: Rat,Rabbit,Horse) |
產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
理論分子量 | 36kDa |
細(xì)胞定位 | 細(xì)胞膜 分泌型蛋白 |
性 狀 | Liquid |
濃 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human CD23: 221-321/321 <Extracellular> |
亞 型 | IgG |
純化方法 | affinity purified by Protein A |
緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
PubMed | PubMed |
產(chǎn)品介紹 |
The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] Function: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). Subcellular Location: Cell membrane; Single-pass type II membrane protein. Secreted. Note=Also exists as a soluble excreted form. Post-translational modifications: N- and O-glycosylated. Similarity: Contains 1 C-type lectin domain. SWISS: P06734 Gene ID: 2208 Database links: Entrez Gene: 2208 Human Entrez Gene: 14128 Mouse Omim: 151445 Human SwissProt: P06734 Human SwissProt: P20693 Mouse Unigene: 465778 Human Unigene: 1233 Mouse CD23是一種II型跨膜糖蛋白,是存在于B細(xì)胞表面的IgE受體。在慢性B淋巴細(xì)胞白血病(CLL)和小B細(xì)胞淋巴瘤(SLL)為陽性,套細(xì)胞淋巴瘤和小核裂淋巴細(xì)胞淋巴瘤陰性。也表達(dá)于外周血B細(xì)胞的某些亞型、B淋巴細(xì)胞和EB病毒轉(zhuǎn)染的B淋巴瘤細(xì)胞系。CD23是慢性B淋巴細(xì)胞白血病,小B細(xì)胞淋巴瘤診斷和鑒別診斷有用的標(biāo)記物。 |
產(chǎn)品圖片 |
Sample: 293T Cell (Human) Lysate at 30 ug Primary: Anti- CD23 (bs-2490R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 36 kD Observed band size: 50/40 kD
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