| 產(chǎn)品編號(hào) | bs-2488R |
| 英文名稱 | Rabbit Anti-CD6 antibody |
| 中文名稱 | CD6抗體 |
| 別 名 | CD_antigen=CD6; CD6; CD6 antigen Tp120; CD6_HUMAN; FLJ44171; OX52; T cell differentiation antigen CD6; T-cell differentiation antigen CD6; T12; TP120. |
| 研究領(lǐng)域 | 細(xì)胞生物 干細(xì)胞 淋巴細(xì)胞 t-淋巴細(xì)胞 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 70kDa |
| 細(xì)胞定位 | 細(xì)胞膜 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD6: 251-350/668 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
CD6 is a type I membrane protein expressed by thymocytes, mature T cells, a subset of B cells known as B1 cells, and some cells in the brain. CD6 is a member of the scavenger receptor cysteine rich (SRCR) family of proteins, which includes the leukocyte antigen CD5. The extracellular domain of CD6 is composed of three SRCR domains and has the same domain organization as CD5. The ligand for CD6 is CD166 also known as activated leukocyte cell adhesion molecule. Through its interaction with CD166 in the thymus, CD6 may have a role in T cell development. Function: Involved in cell adhesion. Binds to CD166. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. Post-translational modifications: After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues. Contains intrachain disulfide bond(s). Similarity: Contains 3 SRCR domains. SWISS: P30203 Gene ID: 923 Database links: Entrez Gene: 923 Human Omim: 186720 Human SwissProt: P30203 Human Unigene: 57361 Rat CD6是I型整合膜糖蛋白,屬于SRCRSF（ scavenger receptor cysteine-rich superfamily）成員。CD6在外周血T細(xì)胞和髓質(zhì)的胸腺細(xì)胞表面表達(dá),也表達(dá)在皮質(zhì)的胸腺細(xì)胞、B1細(xì)胞、某些NK細(xì)胞、腦細(xì)胞、T細(xì)胞或B細(xì)胞的慢性白血病細(xì)胞上。 CD6參與T細(xì)胞活化,調(diào)節(jié)T細(xì)胞功能和介導(dǎo)細(xì)胞-細(xì)胞間的粘附。CD6分子可與TCR/CD3形成復(fù)合體，參與免疫突觸（immunological synapse，IS）的形成。 在自身性免疫性疾病發(fā)病機(jī)制中，T細(xì)胞增殖活化和遷移過(guò)程起著重要作用?；贑D6分子在淋巴細(xì)胞成熟、活化和增殖中的重要作用，阻斷CD6分子的功能可為類風(fēng)濕性關(guān)節(jié)炎、銀屑病等自身免疫的治療提供新的治療手段和方法. |
| 產(chǎn)品圖片 |
Sample:
Jurkat(Human) Cell Lysate at 30 ug
Primary: Anti-CD6 (bs-2488R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 70 kD
Observed band size: 68 kD
|
