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Rabbit Anti-Cathepsin H  antibody (bs-1670R)  
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產品編號 bs-1670R
英文名稱 Rabbit Anti-Cathepsin H  antibody
中文名稱 組織蛋白酶H抗體
別    名 CTSH; Cathepsin H; Activation peptide; ACC4; ACC5; CPSB; cath-H; CH; Ctsh; CATH_HUMAN; Pro-cathepsin H.  
研究領域 細胞生物  免疫學  轉錄調節因子  合成與降解  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Mouse (predicted: Rat,Rabbit,Pig,Cow,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cathepsin H Activation peptide: 71-170/335 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cathepsins B, L, H, K, S, and O. The aspartyl protease class is composed of cathepsins D and E. Cathepsin G is in the serine protease class. Most cathepsins are lysosomal and each is involved in various cellular events such as peptide biosynthesis and protein degradation. The propeptide region of cathepsin H is highly homologous to other cathepsins. This region is thought to play a role in the processing of cysteine proteases. Cathepsin H is thought to be involved in several pathological conditions, including neuro degenerative disorders and cancer.

Function:
Important for the overall degradation of proteins in lysosomes.

Subunit:
Composed of a mini chain and a large chain. The large chain may be split into heavy and light chain. All chains are held together by disulfide bonds.

Subcellular Location:
Lysosome.

Similarity:
Belongs to the peptidase C1 family.

SWISS:
P09668

Gene ID:
1512

Database links:

Entrez Gene: 1512 Human

Entrez Gene: 25425 Rat

Omim: 116820 Human

SwissProt: P09668 Human

SwissProt: P00786 Rat

Unigene: 148641 Human

Unigene: 1997 Rat



產品圖片
Paraformaldehyde-fixed, paraffin embedded (Human kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Cathepsin H) Polyclonal Antibody, Unconjugated (bs-1670R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (mouse kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Cathepsin H) Polyclonal Antibody, Unconjugated (bs-1670R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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