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Rabbit Anti-Cathepsin K  antibody (bs-1611R)  
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產品編號 bs-1611R
英文名稱 Rabbit Anti-Cathepsin K  antibody
中文名稱 組織蛋白酶K抗體
別    名 Cathepsin K; Procathepsin K; Cathepsin K precursor; Cathepsin O; Cathepsin O1; Cathepsin O2; Cathepsin X; CathepsinK; CTS02; CTSK; CTSK protein; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD; Pycnodysostosis; cath-K; CK.  
Specific References  (11)     |     bs-1611R has been referenced in 11 publications.
[IF=14.976] Qinyu Ma. et al. Small extracellular vesicles deliver osteolytic effectors and mediate cancer‐induced osteolysis in bone metastatic niche. J Extracell Vesicles. 2021 Feb;10(4):e12068  WB ;  Mouse.  
[IF=7.419] Xiaoyu Cai. et al. Secretory phosphoprotein 1 secreted by fibroblast-like synoviocytes promotes osteoclasts formation via PI3K/AKT signaling in collagen-induced arthritis. BIOMED PHARMACOTHER. 2022 Nov;155:113687  FC ;  Mouse.  
[IF=7.088] Xinyi Qi. et al. Briarane-type diterpenoids, the inhibitors of osteoclast formation by interrupting Keap1-Nrf2 interaction and activating Nrf2 pathway. EUR J MED CHEM. 2023 Jan;246:114948  WB ;  Mouse.  
[IF=6.304] Chen Y et al. Dendritic cells-derived interferon-λ1 ameliorated inflammatory bone destruction through inhibiting osteoclastogenesis. Cell Death Dis. 2020 Jun 2;11(6):414.  WB ;  Mouse.  
[IF=5.811] Lingli Ding. et al. Ginsenoside Compound K Enhances Fracture Healing via Promoting Osteogenesis and Angiogenesis.. FRONT PHARMACOL. 2022 Apr;13:855393-855393  IF ;  Rat.  
[IF=4.831] Chen Y et al. Epothilone B prevents lipopolysaccharide-induced inflammatory osteolysis through suppressing osteoclastogenesis via STAT3 signaling pathway. Aging (Albany NY). 2020 Jun 11;12(12):11698-11716.  WB ;  Mouse.  
[IF=4.486] Jianye Yang. et al. Astragalus polysaccharide attenuates LPS-related inflammatory osteolysis by suppressing osteoclastogenesis by reducing the MAPK signalling pathway. 2021 Jun 02  WB ;  Mouse.  
[IF=3.448] Ma Q et al. Non‐coenzyme role of vitamin B1 in RANKL‐induced osteoclastogenesis and ovariectomy induced osteoporosis. J Cell Biochem. 2020 Feb 26.  WB ;  mouse.  
[IF=3.448] Hussein NJ et al. A novel regulatory role of TRAPPC9 in L‐plastin‐mediated osteoclast actin ring formation. J Cell Biochem. 2019 Aug 27.  WB ;  Mouse.  
[IF=3.266] Ma Q et al. Vitamin B5 inhibit RANKL induced osteoclastogenesis and ovariectomy induced osteoporosis by scavenging ROS generation. Am J Transl Res. 2019 Aug 15;11(8):5008-5018. eCollection 2019.  WB ;  Mouse.  
[IF=1.26] Zhao et al. Decreased cathepsin K levels in human atherosclerotic plaques are associated with plaque instability. (2017) Exp.Ther.Med. 14:3471-3476  IHC-P ;  Human.  
研究領域 合成與降解  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,Rat (predicted: Human,Pig,Cow,Dog,GuineaPig,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 36kDa
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cathepsin K: 112-210/329 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq, Jul 2008].

Function:
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

Subunit:
Belongs to the peptidase C1 family.

Subcellular Location:
Lysosome.

Tissue Specificity:
Tissue specificityPredominantly expressed in osteclasts (bones).

DISEASE:
Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.

Similarity:
Belongs to the peptidase C1 family.

SWISS:
P43235

Gene ID:
1513

Database links:

Entrez Gene: 1513 Human

Entrez Gene: 13038 Mouse

Entrez Gene: 29175 Rat

Omim: 601105 Human

SwissProt: P43235 Human

SwissProt: P55097 Mouse

SwissProt: O35186 Rat

Unigene: 632466 Human

Unigene: 272085 Mouse

Unigene: 5598 Rat



合成與降解(Synthesis and Degradation)
組織蛋白酶K(cathepsinK)是半胱氨酸蛋白酶家族的成員,它和組織蛋白酶S、L和B有很高的同源性。
在心血管方面:組織蛋白酶K參與心血管的很多病理生理過程,在動脈硬化、血管重塑與再生。也是動脈瘤生長、破裂、主動脈辯狹窄進程中主要的膠原酶之一。 在骨與關節方面:組織蛋白酶K主要位于破骨細胞,是涉及骨質再吸收的主要酶,與骨質疏松與脫鈣密切相關。
產品圖片
Sample: Lane 1: Mouse Raw264.7 cell lysates Lane 2: Mouse 4T1 cell lysates Primary: Anti-Cathepsin K (bs-1611R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 36 kDa Observed band size: 46 kDa
Tissue/cell: mouse heart tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Cathepsin K Polyclonal Antibody, Unconjugated(bs-1611R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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