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Rabbit Anti-Thrombomodulin  antibody (bs-0525R)  
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產(chǎn)品編號 bs-0525R
英文名稱 Rabbit Anti-Thrombomodulin  antibody
中文名稱 血栓調(diào)節(jié)蛋白抗體
別    名 CD 141; CD141; CD141 antigen; Fetomodulin; THBD; THRM; TM; AHUS 6; AHUS6; BDCA 3; BDCA3; THPH12; TRBM_HUMAN.  
Specific References  (2)     |     bs-0525R has been referenced in 2 publications.
[IF=3.905] Weifeng Hu. et al. Bone marrow-derived mesenchymal stem cells transplantation attenuates renal fibrosis following acute kidney injury by repairing the peritubular capillaries. Exp Cell Res. 2022 Feb;411:112983  IHC ;  Rat.  
[IF=3.508] Juin-Hong Cherng. et al. Hemostasis and Anti-Inflammatory Abilities of AuNPs-Coated Chitosan Dressing for Burn Wounds. J PERS MED. 2022 Jul;12(7):1089  IHC ;  Rat.  
研究領(lǐng)域 心血管  細(xì)胞生物  神經(jīng)生物學(xué)  血管內(nèi)皮細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,Mouse,Rat (predicted: Cow,Dog)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 61kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse Thrombomodulin: 301-400/575 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Thrombomodulin, TM is cell surface glycoprotein; plays an important role in the protein C anticoagulant pathway. It located in a vein, artery and capillary endothelial cells on the surface of plasma membrane protein. It is generally believed: TM vascular endothelial injury is an important parameter is the thrombin receptor, known in a variety of normal human tissues, can also be expressed in many tumors, TM may be similar to the E-cadherin,and is a lectin Like activity of a new class of members of the cell adhesion molecules.
CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

Function:
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Endothelial cells are unique in synthesizing thrombomodulin.

Post-translational modifications:
N-glycosylated.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

DISEASE:
Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THPH12) [MIM:614486]. A hemostatic disorder characterized by a tendency to thrombosis.
Defects in THBD are a cause of susceptibility to hemolytic uremic syndrome atypical type 6 (AHUS6) [MIM:612926]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.

Similarity:
Contains 1 C-type lectin domain.
Contains 6 EGF-like domains.

SWISS:
P07204

Gene ID:
7056

Database links:

Entrez Gene: 7056 Human

Omim: 188040 Human

SwissProt: P07204 Human

Unigene: 2030 Human



血栓調(diào)節(jié)蛋白(thrombomodulin,TM)是一種分布于靜脈、動脈和毛細(xì)血管內(nèi)皮細(xì)胞表面的質(zhì)膜蛋白。 一般認(rèn)為:TM是血管內(nèi)皮損傷的重要參數(shù),也是凝血酶的受體,已知在人類多種正常組織中表達(dá),亦可表達(dá)于許多腫瘤組織,TM可能類似于鈣粘蛋白,是具有凝集素樣活性的新一類細(xì)胞粘附分子的成員。TM是血管內(nèi)皮細(xì)胞膜上的凝血酶受體之一。與凝血酶結(jié)合后可降低凝血酶的凝血活性,而加強(qiáng)其激活蛋白C的活性。由于被激活的蛋白C具有抗凝作用,因此,TM是使凝血酶由促凝轉(zhuǎn)向抗凝的重要的血管內(nèi)凝血抑制因子。
產(chǎn)品圖片
Sample: Lane 1: Testis (Mouse) Tissue Lysate at 40 ug Lane 2: NIH/3T3 (Mouse) Cell Lysate at 30 ug Lane 3: Testis (Rat) Tissue Lysate at 40 ug Lane 4: A431 (Human) Cell Lysate at 30 ug Lane 5: Huvec (Human) Cell Lysate at 30 ug Lane 6: A549 (Human) Cell Lysate at 30 ug Primary: Anti-Thrombomodulin (bs-0525R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 61 kD Observed band size: 120 kD
(IHC)Immunohistochemistry Tissue/cell: human kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Thrombomodulin Polyclonal Antibody, Unconjugated(bs-0525R) 1:300, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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