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Rabbit Anti-TIMP-3  antibody (bs-0417R)  
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產(chǎn)品編號 bs-0417R
英文名稱 Rabbit Anti-TIMP-3  antibody
中文名稱 金屬蛋白酶組織抑制因子-3抗體
別    名 HSMRK222; K222; K222TA2; Metalloproteinase inhibitor 3; TIMP3; TIMP 3; MIG 5 protein; MIG5 protein; Protein MIG 5; SFD; Sorsby fundus dystrophy pseudoinflammatory; TIMP metallopeptidase inhibitor 3; TIMP3; Tissue Inhibitor of Metalloproteinase 3; Tissue inhibitor of metalloproteinases3; TIMP3_HUMAN.  
Specific References  (7)     |     bs-0417R has been referenced in 7 publications.
[IF=5.064] Xia Liu. et al. The adipokine orosomucoid alleviates adipose tissue fibrosis via the AMPK pathway. Acta Pharmacol Sin. 2021 Apr;:1-9  WB ;  Mouse.  
[IF=4.24] Peng, Jiayin, et al. "Expression and regulative function of tissue inhibitor of metalloproteinase 3 in the goat ovary and its role in cultured granulosa cells."Molecular and Cellular Endocrinology (2015).  WB ;  Goat.  
[IF=3.98] Liu, Wen-bin, et al. "Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a." Toxicology and applied pharmacology 251.1 (2011): 70-78.  IHC-P ;  Rat.  
[IF=3.902] David Santeret al. Tenascin‐C aggravates ventricular dilatation and angiotensin‐converting enzyme activity after myocardial infarction in mice. ESC Heart Fail . 2020 Oct;7(5):2113-2122.  IHC ;  mouse.  
[IF=2.14] Lu, Minling, et al. "The effects of mycotoxins and selenium deficiency on tissue-engineered cartilage." Cells Tissues Organs 196.3 (2012): 241-250.  IHC-P ;  Rabbit.  
[IF=1.8] Han, Jing, et al. "Long-Term Selenium-Deficient Diet Induces Liver Damage by Altering Hepatocyte Ultrastructure and MMP1/3 and TIMP1/3 Expression in Growing Rats." Biological Trace Element Research (2016): 1-9.  IHC-P ;  Rat.  
[IF=1.8] Peng, Jiayin, et al. "Expression and regulation of tissue inhibitors of metalloproteinases (TIMP1 and TIMP3) in goat oviduct." Theriogenology(2015).  IHC-P ;  Goat.  
研究領(lǐng)域 腫瘤  心血管  細胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細胞凋亡  合成與降解  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human (predicted: Mouse,Rat,Rabbit,Pig,Cow,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 21kDa
細胞定位 細胞外基質(zhì) 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TIMP-3: 151-211/211 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008].

Subunit:
Interacts with EFEMP1.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Similarity:
Belongs to the protease inhibitor I35 (TIMP) family.
Contains 1 NTR domain.

SWISS:
P35625

Gene ID:
7078

Database links:

Entrez Gene: 7078 Human

Entrez Gene: 21859 Mouse

Entrez Gene: 25358 Rat

Omim: 188826 Human

SwissProt: P35625 Human

SwissProt: P39876 Mouse

SwissProt: P48032 Rat

Unigene: 644633 Human



合成與降解(Synthesis and Degradation)
近年來,國內(nèi)外科研人員對TIMP-3的抗腫瘤作用日益被重視,學(xué)者認(rèn)為:TIMP-3具有強烈促凋亡、抑制血管生成、抗腫瘤浸潤作用,TIMP-3與TIMP-1、2且相互間有明顯協(xié)同抗腫瘤作用
產(chǎn)品圖片
Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-TIMP-3 Polyclonal Antibody, Unconjugated(bs-0417R) 1:100, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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