国产亚洲欧美二区,欧美巨大另类极品videosbest,久久国产精品偷,超刺激h直播间play

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  人才招聘  關于我們  聯系我們
国产免费1卡2卡,尤物丰满少妇大尺度喷血写真,唐人呦一呦xxxx视频
首頁 > 產品中心 > 一抗 > 產品信息
Rabbit Anti-CD105  antibody (bs-0579R)  
~~~促銷代碼KT202411~~~
訂購熱線:400-901-9800
訂購郵箱:sales@ythxkj.com
訂購QQ:  400-901-9800
技術支持:techsupport@ythxkj.com
說明書: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-0579R
英文名稱 Rabbit Anti-CD105  antibody
中文名稱 CD105抗體
別    名 END; Endoglin; ENG; FLJ41744; HHT1; ORW; ORW1; Osler Rendu Weber syndrome 1; RP11 228B15.2; CD 105; CD105 antigen; EGLN_HUMAN; AI528660; AI662476; S-endoglin; SN6.  
Specific References  (26)     |     bs-0579R has been referenced in 26 publications.
[IF=8.724] Yong Tang. et al. Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering. Bioact Mater. 2021 Jul;6:2039  IF,IHC ;  Mouse.  
[IF=8.579] Jipeng Jiang. et al. Implantation of regenerative complexes in traumatic brain injury canine models enhances the reconstruction of neural networks and motor function recovery. Theranostics. 2021; 11(2): 768–788  FC ;  Human.  
[IF=8.352] Chanjuan Dong. et al. Graphene-based conductive fibrous scaffold boosts sciatic nerve regeneration and functional recovery upon electrical stimulation. Appl Mater Today. 2020 Dec;21:100870  IHC ;  Rat.  
[IF=7.328] Dongdong Yao. et al. Matrix stiffness regulates bone repair by modulating 12-lipoxygenase-mediated early inflammation. Mat Sci Eng C-Mater. 2021 Sep;128:112359  IF ;  Mouse.  
[IF=7.242] Yong Tang. et al. Laminin alpha 4 promotes bone regeneration by facilitating cell adhesion and vascularization. Acta Biomater. 2021 Mar;:  IF ;  Mouse.  
[IF=6.832] Wei-Cheng Tseng. et al. Hypoxic mesenchymal stem cells ameliorate acute kidney ischemia-reperfusion injury via enhancing renal tubular autophagy. Stem Cell Res Ther. 2021 Dec;12(1):1-22  FC ;  Rat.  
[IF=5.999] Jinsheng Li. et al. Micro/nano-topography Promotes Osteogenic Differentiation of Bone Marrow Stem Cells by Regulating Periostin Expression. COLLOID SURFACE B. 2022 Jul;:112700  FC ;  Rat.  
[IF=4.996] Shirai, Yuuki. et al. Bone marrow-derived vasculogenesis leads to scarless regeneration in deep wounds with periosteal defects. SCI REP-UK. 2022 Nov;12(1):1-12  IHC ;  Rat.  
[IF=4.714] Emma Heyman. et al. Validation of multiparametric panels for bovine mesenchymal stromal cell phenotyping. CYTOM PART A. 2023 May;:  FCM ;  Bovine.  
[IF=4.648] Long et al. Mash1-dependent Notch Signaling Pathway Regulates GABAergic Neuron-Like Differentiation from Bone Marrow-Derived Mesenchymal Stem Cells. (2017) Aging.Di. 8:301-313  FCM ;  Rat.  
[IF=3.78] Dong Z et al. Proteomic profiling of stem cell tissues during regeneration of deer antler-a model of mammalian organ regeneration. J Proteome Res. 2020 Apr 3;19(4):1760-1775.  IHC ;  deer.  
[IF=3.65] Boopathy, Archana V., et al. "Oxidative stress-induced Notch1 signaling promotes cardiogenic gene expression in mesenchymal stem cells." Stem cell research & therapy 4.2 (2013): 1-15.  FCM ;  Rat.  
[IF=3.427] Gao et al. Common expression of stemness molecular markers and early cardiac transcription factors in human Wharton's jelly-derived mesenchymal stem cells and embryonic stem cells. (2013) Cell.Transplan. 22:1883-900  FCM ;  Human.  
[IF=3.231] Zhen Zhou. et al. Myogenic Determination and Differentiation of Chicken Bone Marrow-Derived Mesenchymal Stem Cells under Different Inductive Agents. ANIMALS. 2022 Jan;12(12):1531  IF ;  Chicken.  
[IF=2.984] Heli Zhang. et al. FN1 promotes chondrocyte differentiation and collagen production via TGF-β/PI3K/Akt pathway in mice with femoral fracture. Gene. 2021 Feb;769:145253  IHC ;  Mouse.  
[IF=2.768] Hussien et al. Combination of Obestatin and Bone Marrow Mesenchymal Stem Cells Prevents Aggravation of Endocrine Pancreatic Damage in Type II Diabetic Rats. (2017) Int.J.Stem.Cells. 10:129-143  IHC-P ;  Rat.  
[IF=2.66] Li et al. Perichondrium mesenchymal stem cells inhibit the growth of breast cancer cells via the DKK-1/Wnt/β-catenin signaling pathway. (2016) Oncol.Rep. 36:936-44  IF(ICC) ;  Rat.  
[IF=2.634] Ma?C et al. Identification and Multilineage Potential Research of a Novel Type of Adipose-Derived Mesenchymal Stem Cells from Goose Inguinal Groove. DNA Cell Biol. 2018 Sep;37(9):731-741.  ICF ;  Goose.  
[IF=2.31] Fan, Hai-Xia, et al. "Expression of MMP-1/PAR-1 and patterns of invasion in oral squamous cell carcinoma as potential prognostic markers." OncoTargets and therapy 8 (2015): 1619.  IHC-P ;  Human.  
[IF=2.172] Yuchen Yao. et al. Seasonal expressions of VEGF and its receptors VEGFR1 and VEGFR2 in the prostate of the wild ground squirrels (Spermophilus dauricus). Eur J Histochem. 2021 Mar 24; 65(2): 3219  IHC ;  squirrel.  
[IF=1.64] Naderi‐Meshkin, Hojjat, et al. "Injectable hydrogel delivery plus preconditioning of mesenchymal stem cells: exploitation of SDF‐1/CXCR4 axis towards enhancing the efficacy of stem cells homing." Cell Biology International (2015).  FCM ;  Rat.  
[IF=1.52] Tepekoy, Filiz, et al. "CD90 and CD105 expression in the mouse ovary and testis at different stages of postnatal development." Reproductive Biology(2015).  IHC-P ;  Mouse.  
[IF=1.461] Pei?W et al. Biological characterization and pluripotent identification of ovine amniotic fluid stem cells. Cytotechnology. 2018 Jun;70(3):1009-1021.  IF&FCM ;  ovine embryo.  
[IF=0.918] Chen F et al. The biological characteristics of sheep umbilical cord mesenchymal stem cells.Can J Vet Res. 2018 Jul;82(3):216-224.  ICF ;  lamb.  
[IF=0.52] Utomo, Pamudji, et al. ""Decreasing SDF1-CXCR4 Expression after Adipose-Derived Mesenchymal Stem Cells (ASCS) Treatment Combined with Freeze-Dried Amniotic Membrane Wrapping in Rat Sciatic Nerve Injury."" International Journal of ChemTech Research.  IF(ICC) ;  Rat.  
[IF=]   ELISA, WB ;  rat.  
研究領域 腫瘤  心血管  細胞生物  免疫學  信號轉導  干細胞  生長因子和激素  細胞膜受體  細胞表面分子  內皮細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,Flow-Cyt=2ug/Test,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 70kDa
檢測分子量 90
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD105: 601-658/658 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]

Function:
Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.

Subunit:
Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Endoglin is restricted to endothelial cells in all tissues except bone marrow.

DISEASE:
Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.

SWISS:
P17813

Gene ID:
2022

Database links:

Entrez Gene: 2022 Human

Omim: 131195 Human

SwissProt: P17813 Human

Unigene: 76753 Human



細胞膜受體(Membrane Receptors)
CD105(Endoglin):CD105是一種存在于細胞表面的同源二聚體跨膜糖蛋白,是TGF-β受體復合物的組成部分,是TGF-β的附屬受體,能與多種TGF-β超家族成員結合尤其與TGF-β1、TGF-β3有很高的親和力,調節TGF-βs與其受體結合而參與信號傳導,是內皮細胞增殖相關膜抗原,在培養的高增殖活性內皮細胞和許多惡性腫瘤組織血管內皮細胞中高表達,參與血管生成,但其在血管生成調節中的作用機制尚未闡明。主要用于各種惡性腫瘤組織中的血管生成的研究.
CD105(Endoglin):CD105是一種分子量為180kDa的存在于細胞表面的同源二聚體跨膜糖蛋白,是TGF-β受體復合物的組成部分,是TGF-β的附屬受體,能與多種TGF-β超家族成員結合尤其與TGF-β1、TGF-β3有很高的親和力,調節TGF-βs與其受體結合而參與信號傳導,是內皮細胞增殖相關膜抗原,在培養的高增殖活性內皮細胞和許多惡性腫瘤組織血管內皮細胞中高表達,參與血管生成,但其在血管生成調節中的作用機制尚未闡明。CD105基因定位于人9號染色體,是Ⅰ型遺傳性出血性毛細血管擴張癥的相關基因。CD105基因敲除小鼠胚胎因血管生成缺陷而于受精后平均11.5天死亡,故有學者認為,CD105可能與血管生成啟動有關,可用于標記腫瘤新生血管。 Endoglin是內皮細胞表面與細胞增殖相關的膜抗原,也是轉化生長因子β超家族受體復合物成分之一。其具有調節內皮細胞對TGF的反應、促內皮細胞增殖和促血管形成等功能,與腫瘤血管的發生密切相關。近年來,Endoglin在腫瘤診斷、判斷預后和療效及抗腫瘤血管靶向治療等方面的作用得到重視。姬,2017.1.15;
產品圖片
Paraformaldehyde-fixed, paraffin embedded Human Colon Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with CD105 Polyclonal Antibody, Unconjugated (bs-0579R) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit, SP-0023) and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Liver Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with CD105 Polyclonal Antibody, Unconjugated (bs-0579R) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit, SP-0023) and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with CD105 Polyclonal Antibody, Unconjugated (bs-0579R) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit, SP-0023) and DAB (C-0010) staining.
Blank control:Hela. Primary Antibody (green line): Rabbit Anti-CD105 antibody (bs-0579R) Dilution: 2ug/Test; Secondary Antibody : Goat anti-rabbit IgG-FITC Dilution: 0.5ug/Test. Protocol The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
版權所有 2004-2026 www.ythxkj.com 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號